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CXCL12/CXCR4 display an inverse mRNA expression profile in gastric carcinoma which correlates with tumor progression
02 August 2017 (online)
Chemokines and their receptors have been shown to contribute to tumor growth and metastatic spread in various gastrointestinal cancer entities.
In this study, the mRNA expression profile and clinical significance of chemokine ligand CXCL12 and its corresponding receptor CXCR4 have been investigated in gastric cancer (GC) patients.
Using RealTime-PCR we analyzed the expression profile of CXCL12/CXCR4 in resection specimens from patients with GC (n = 66) as well as in corresponding normal gastric tissues.
Investigating CXCL12/CXCR4 mRNA expression in GC tissues we demonstrated a significant down-regulation of CXCL12 (P < 0.05) whereas CXCR4 mRNA expression was shown to be significantly up-regulated (P < 0.05). Likewise, in gastric carcinoma patients undergoing neoadjuvant chemotherapy CXCR4 expression was found to be significantly up-regulated whereas in GC patients with lymph and vene infiltration CXCL12 mRNA expression was significantly down-regulated (P < 0.05, respectively).
Our results demonstrate a significant inversely related association between the development and progress of GC and CXCL12/CXCR4 mRNA expression. Thus, CXCR4 mRNA up-regulation was promoted under the influence of neoadjuvant chemotherapy prior to surgery in GC patients whereas higher tumor stages with lymph and vene infiltration negatively affected CXCL12 mRNA expression.