J Pediatr Intensive Care 2018; 07(02): 069-074
DOI: 10.1055/s-0037-1604422
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Medication Use as a Contributor to Fluid Overload in the PICU: A Prospective Observational Study

Dana Fuhrman
1  Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
,
Kelli Crowley
1  Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
,
Carol Vetterly
1  Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
,
Keito Hoshitsuki
1  Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
,
Alaina Koval
1  Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
,
Joseph Carcillo
1  Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
› Author Affiliations
Further Information

Publication History

10 May 2017

24 June 2017

Publication Date:
26 July 2017 (eFirst)

Abstract

In this prospective observational study, we explored the association of daily fluid intake from medication use with fluid overload in 75 children beginning 24 hours after intubation. The mean percent daily fluid intake from medications was 29% in the overall cohort. Excess intake and inadequate output contributed significantly to fluid overload. In the 28 patients who became ≥10% fluid overloaded, the mean percent daily fluid intake from medications was 34%, but just 23% in the patients who did not. Awareness of volume contribution and maximized concentration of parenteral medications when able may lessen the burden of fluid overload.