CC-BY-NC-ND 4.0 · AJP Rep 2017; 07(03): e163-e166
DOI: 10.1055/s-0037-1604407
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Infant Botulism in the Very Young Neonate: A Case Series

Laura Jackson1, Suneeta Madan-Khetarpal2, Monica Naik3, Marian G. Michaels4, Melissa Riley1
  • 1Division of Newborn Medicine, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
  • 2Division of Medical Genetics, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
  • 3Division of Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
  • 4Division of Infectious Disease, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Further Information

Publication History

24 April 2017

14 June 2017

Publication Date:
31 July 2017 (online)

Abstract

Background Though botulism is a rare disease overall, all infants younger than 1 year of age are at risk of contracting infant botulism, the most prevalent form reported in the United States. Nonetheless, infant botulism is frequently omitted from the differential diagnosis of the very young neonate exclusively due to age, and the diagnosis is often only considered secondarily after a costly and prolonged work up is undertaken. Delayed diagnosis can lead not only to unnecessary testing but also to prolonged hospital stay and increased morbidity.

Case This case series highlights three critically ill neonates, all younger than 30 days, who presented to our neonatal intensive care unit and were eventually diagnosed with infant botulism. The initial diagnostic dilemma is described for each of these patients and highlights the importance of early recognition of the main symptoms, in addition to consideration of important potential coinciding conditions.