J Neurol Surg B Skull Base 2018; 79(02): 117-122
DOI: 10.1055/s-0037-1604363
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Diabetes Insipidus following Endoscopic Transsphenoidal Surgery for Pituitary Adenoma

Abdulrazag M. Ajlan
1   Department of Neurosurgery, Stanford University, Palo Alto, California, United States
2   Department of Neurosurgery, King Saud University, Riyadh, Saudi Arabia
Sarah Bin Abdulqader
3   College of Medicine, King Saud University, Riyadh, Saudi Arabia
Achal S. Achrol
1   Department of Neurosurgery, Stanford University, Palo Alto, California, United States
Yousef Aljamaan
4   College of Medicine, University of Dammam, Dammam, Saudi Arabia
Abdullah H. Feroze
1   Department of Neurosurgery, Stanford University, Palo Alto, California, United States
Laurence Katznelson
1   Department of Neurosurgery, Stanford University, Palo Alto, California, United States
5   Department of Medicine, Stanford University, Palo Alto, California, United States
Griffith R. Harsh
1   Department of Neurosurgery, Stanford University, Palo Alto, California, United States
› Author Affiliations
Further Information

Publication History

26 January 2017

14 June 2017

Publication Date:
03 August 2017 (online)


Objectives Pituitary adenoma (PA), among the most commonly encountered sellar pathologies, accounts for 10% of primary intracranial tumors. The reported incidence of postoperative diabetes insipidus (DI) is highly variable. In this study, we report our experience with DI following endoscopic transsphenoidal surgery (TSS) for PAs, elucidating the risk factors of postoperative DI, the likelihood of long-term DI, and the impact of DI on the length of stay (LOS).

Methods The study included 178 patients who underwent endoscopic resection of PAs. Early DI was defined as that occurring within the first postoperative week. The mean follow-up was 36 months. Long-term DI was considered as DI apparent in the last follow-up visit.

Results Of the 178 patients included in the study, 77% of the tumors were macroadenomas. Forty-seven patients (26%) developed early DI. Long-term DI was observed in 18 (10.1%) of the full cohort. Age younger than 50 years was significantly associated with a higher incidence of long-term DI (p = 0.02). Macroadenoma and gross total resection were significantly associated with higher incidence of early DI (p = 0.05 and p = 0.04, respectively). The mean LOS was 4 days for patients with early postoperative DI and 3 days for those without it.

Conclusion The reported incidence of postoperative DI is significantly variable. We identified age younger than 50 years a risk factor for developing long-term postoperative DI. Gross total surgical resection and tumor size (> 1 cm) were associated with development of early DI. Early DI increased the LOS on average by 1 day.

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