J Pediatr Epilepsy 2017; 06(03): 133-140
DOI: 10.1055/s-0037-1604354
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Factors Associated with Attention Deficit Hyperactivity Disorder in Children with Frontal Lobe Epilepsy

Hideaki Kanemura
Department of Pediatrics, University of Yamanashi, Yamanashi, Japan
,
Fumikazu Sano
Department of Pediatrics, University of Yamanashi, Yamanashi, Japan
,
Tetsuo Ohyama
Department of Pediatrics, University of Yamanashi, Yamanashi, Japan
,
Kanji Sugita
Department of Pediatrics, University of Yamanashi, Yamanashi, Japan
,
Masao Aihara
Department of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan
› Author Affiliations
Further Information

Publication History

01 May 2017

19 June 2017

Publication Date:
25 July 2017 (eFirst)

Abstract

The relationship between attention deficit/hyperactivity disorder (ADHD) and frontal lobe epilepsy (FLE) in children is not well understood. Patients with FLE between 6 and 15 years of age were studied. Scores on the ADHD rating scale (ADHD-RS) and Wisconsin card sorting test (WCST) were obtained at baseline. Behavioral changes were evaluated using the ADHD-RS scores at 6, 12, and 24 months after seizure onset. Perseverative errors of Nelson (PEN) scales on WCST were also evaluated at same time periods. The relationships between clinical manifestations and neuropsychological disturbances were analyzed. In 34 patients, the ADHD-RS score at 24 months after onset was most strongly associated with the presence of status epilepticus (SE, p = 0.004, β = 0.490) followed by seizure frequency (p = 0.021, β = 0.382). The increase in ADHD-RS score was most strongly associated with seizure frequency (p < 0.001, β = 0.635). The PEN score on WCST at 24 months was most strongly associated with seizure frequency (p = 0.001, β = 0.724). The increase in PEN score on WCST was most strongly associated with seizure frequency (p = 0.001, β = 0.872). The only clinical factor associated with both the ADHD-RS and the PEN scores on the WCST was seizure frequency. Seizure frequency may be correlated with risk for ADHD in children with FLE.

Funding

This research was supported in part by The Japan Epilepsy Research Foundation. The funding sources had no involvement in the study design; collection, analysis, and interpretation of data; writing of the report; or the decision to submit the article for publication.