J Pediatr Genet 2017; 06(04): 252-257
DOI: 10.1055/s-0037-1603916
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Placental Teratoma, Omphalomesenteric Duct Remnant, or Intestinal Organoid (Enteroid) Differentiation: A Diagnostic Dilemma

Salwa Khedr
Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island, United States
,
Tarek Jazaerly
Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Kent Hospital, Warwick, Rhode Island, United States
,
Stefan Kostadinov
Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island, United States
› Author Affiliations
Further Information

Publication History

01 May 2017

18 May 2017

Publication Date:
12 June 2017 (eFirst)

Abstract

We report an unusual case of fully developed fetal intestinal segment(s) within a nodule on the chorionic plate of the placenta of a 27-year-old female patient at 37 weeks gestation with spontaneous vaginal delivery. Gross examination of the placenta revealed a chorionic plate nodule near the insertion of the umbilical cord, which, upon microscopic evaluation, raised the differential diagnostic possibilities of placental teratoma, vitelline/omphalomesenteric duct anomaly, and intestinal organoid differentiation. We discuss the distinguishing features, morphogenesis, and clinical significance of the aforementioned entities and review the pertinent medical literature.