J Pediatr Genet 2017; 06(04): 252-257
DOI: 10.1055/s-0037-1603916
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Placental Teratoma, Omphalomesenteric Duct Remnant, or Intestinal Organoid (Enteroid) Differentiation: A Diagnostic Dilemma

Salwa Khedr1, Tarek Jazaerly2, Stefan Kostadinov1
  • 1Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island, United States
  • 2Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Kent Hospital, Warwick, Rhode Island, United States
Further Information

Publication History

01 May 2017

18 May 2017

Publication Date:
12 June 2017 (eFirst)

Abstract

We report an unusual case of fully developed fetal intestinal segment(s) within a nodule on the chorionic plate of the placenta of a 27-year-old female patient at 37 weeks gestation with spontaneous vaginal delivery. Gross examination of the placenta revealed a chorionic plate nodule near the insertion of the umbilical cord, which, upon microscopic evaluation, raised the differential diagnostic possibilities of placental teratoma, vitelline/omphalomesenteric duct anomaly, and intestinal organoid differentiation. We discuss the distinguishing features, morphogenesis, and clinical significance of the aforementioned entities and review the pertinent medical literature.