CC BY-NC-ND 4.0 · AJP Rep 2017; 07(02): e111-e115
DOI: 10.1055/s-0037-1603890
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Etiology and Perinatal Outcome of Nonimmune Hydrops Fetalis in Southern China

Sheng He*
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Linlin Wang*
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Pingshan Pan
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Hongwei Wei
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Dahua Meng
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Juan Du
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Xiaoxian Tian
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Chenguang Zheng
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Xiaoxia Qiu
1  Prenatal Diagnosis Center, Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning, People's Republic of China
,
Guoyang Luo
2  Department of Obstetrics and Gynecology, University of Connecticut, Farmington, Connecticut
› Author Affiliations
Further Information

Publication History

04 March 2017

11 May 2017

Publication Date:
12 June 2017 (online)

  

Abstract

Objective This study aims to analyze the etiology and perinatal outcome of nonimmune hydrops fetalis (NIHF) in Southern China.

Methods All cases with NIHF diagnosed antenatally from January 1, 2007 to December 31, 2014 were identified and analyzed.

Results Total 482 cases of NIHF were identified during the study period. The most common cause of NIHF was hemoglobin (Hb) Bart's disease (61.8%), followed by chromosomal abnormalities (13.5%), idiopathic etiology (13.1%), cardiac abnormalities (6.4%), and others (5.2%). After 20 weeks' gestation, a total of 408 cases of NIHF presented, including Hb Bart's disease (279 cases), cardiac abnormalities (27 cases), and infection (7 cases). NIHF caused by chromosomal abnormalities mainly presented between 15 and 19 weeks' gestation. Of the 482 cases, 459 cases elected termination of pregnancy. The remaining 23 cases elected to continue their pregnancy. Among them, 14 (60.9%) resulted in intrauterine fetal death, 6 had neonatal death, 3 infants survived to 1 year of age. Of the three infants, one has cerebral palsy, and the remaining two are normal.

Conclusions Hb Bart's disease is the most common cause of NIHF in Southern China. An effective prenatal screening and counseling program for thalassemia in this region may be the most effective way to lower the incidence NIHF.

Ethical Approval

Guangxi Zhuang Autonomous Region Women and Children Care Hospital Ethics Committee approved the publication of this article.


* Sheng He and LinLin Wang are co–first authors.