Neuropediatrics 2017; 48(06): 463-466
DOI: 10.1055/s-0037-1603642
Short Communication
Georg Thieme Verlag KG Stuttgart · New York

Morning Glory Disc Anomaly Associated with Ipsilateral Optic Nerve and Chiasm Thickening: Three Cases and Review of the Literature

Chiara Doneda1, Lorenzo Pinelli2, Matteo Scaramuzzi3, 4, Jessica Galli5, 6, Elisa Fazzi5, 6, Cecilia Parazzini1, Andrea Righini1, Paolo Nucci3, 4
  • 1Department of Pediatric Radiology and Neuroradiology, Children's Hospital V Buzzi, ASST. Fatebenefratelli Sacco, Milan, Italy
  • 2Department of Diagnostic Imaging, Neuroradiology Unit, Section of Pediatric Neuroradiology, ASST Spedali Civili, Brescia, Italy
  • 3San Giuseppe Hospital, University Eye Clinic, Milan, Italy
  • 4Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
  • 5Unit of Child Neurology and Psychiatry, ASST Spedali Civili, Brescia, Italy
  • 6Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Further Information

Publication History

29 November 2016

25 April 2017

Publication Date:
09 June 2017 (eFirst)


Several extraorbital findings have been described in morning glory disc anomaly (MGDA), including optic pathway abnormalities. We want to emphasize the importance of looking for ipsilateral optic nerve and chiasm thickening in MGDA-affected patients because we think that it may be a relevant common associated finding to date not stressed by anyone. We report three cases of clinically diagnosed unilateral MGDA in which magnetic resonance imaging revealed enlargement of the ipsilateral optic nerve and chiasm. A literature analysis was made and previously reported MGDA cases, and case series were checked, looking for described, or misunderstood similar magnetic resonance imaging findings. Three other cases with very similar prechiasmatic optic nerve and chiasm findings were identified from the literature. Two further cases are discussed as possibly characterized by similar misinterpreted magnetic resonance features. Our study broadens the constellation of intra- and extraorbital findings of MGDA. Though magnetic resonance imaging is not sufficient to determine the neuropathological substrate of this finding, clinicians and radiologists should be aware of the possible association of MGDA with ipsilateral thickening of the optic nerve and chiasm, to properly plan the clinical and imaging follow-up.


No grant support has been given for this study.