J Neurol Surg A Cent Eur Neurosurg 2018; 79(02): 108-115
DOI: 10.1055/s-0037-1603634
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Morphological Effect on Wall Shear Stress in Intracranial Aneurysms

Tian-Lun Qiu
1  Department of Neurosurgery, Shaoxing People's Hospital, Shaoxing, China
,
Guo-Liang Jin
1  Department of Neurosurgery, Shaoxing People's Hospital, Shaoxing, China
,
Wu-Qiao Bao
1  Department of Neurosurgery, Shaoxing People's Hospital, Shaoxing, China
,
Hai-Tao Lu
2  Department of Neurosurgery, Chongming Branch of Shanghai Xinghua Hospital, Shanghai, China
› Author Affiliations
Further Information

Publication History

20 December 2016

05 April 2017

Publication Date:
12 July 2017 (online)

Abstract

Background and Study Aims Both high and low wall shear stress (WSS) play important roles in the development and rupture of intracranial aneurysms (IAs). This study aimed to determine the morphological factors that affect WSS in the IA and the parent artery.

Material and Methods We studied a total of 66 IAs with three-dimensional imaging. Computational fluid dynamics (CFD) models were constructed and used to characterize the hemodynamics quantitatively. Aneurysms were grouped according to the mean neck width. The associations among hemodynamics and morphology were analyzed.

Results Aspect ratio was correlated to lowest WSS (r = − 0.576), aneurysm-to-parent vessel (A-P) WSS ratio (r = − 0.500), and lowest-parent vessel (L-P) WSS ratio (r = − 0.575). Height-to-width ratio and height were correlated to WSS. Mean aneurysm WSS (p = 0.023), lowest WSS (p < 0.0001), highest-to-lowest WSS ratio (p = 0.004), L-P WSS ratio (p < 0.0001), highest-parent vessel (H-P) WSS ratio (p = 0.008), A-P WSS ratio (p < 0.001), and height (p < 0.001) were different between the two groups of aneurysms that were divided by the relationship between the diameters of the aneurysms and the necks. Multivariable analysis showed that the lowest WSS (p = 0.028) and A-P WSS ratio (p = 0.001) were independently associated with neck width.

Conclusion Morphological characteristics are associated with IA and parent vessel WSS. Aneurysms with different neck widths have different hemodynamics. These results could help in understanding the progression of IA and in building predictive models for IA rupture.