CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2018; 22(03): 313-316
DOI: 10.1055/s-0037-1603619
Systematic Review
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Hearing Loss in Acromegaly - A Review

Liane Sousa Teixeira
1   Department of Otolaryngology, Universidade de Brasília, Brasília, DF, Brazil
Isabelle Braz de Oliveira Silva
2   Hearing Health Division, Hospital Universitário de Brasília, Brasília, DF, Brazil
Andre Luiz Lopes Sampaio
1   Department of Otolaryngology, Universidade de Brasília, Brasília, DF, Brazil
Carlos Augusto Pires de Oliveira
1   Department of Otolaryngology, Universidade de Brasília, Brasília, DF, Brazil
Fayez Bahamad Júnior
3   Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, DF, Brazil
› Author Affiliations
Further Information

Publication History

09 October 2016

01 April 2017

Publication Date:
16 June 2017 (online)


Introduction Acromegaly is a chronic disease caused by growth hormone (GH) excess due to a GH-secreting pituitary adenoma in most cases. There is reasonable data to presume the possible influence of chronic GH and insulin-like growth factor I (IGF-I) hyperproduction on the anatomical structures involved in normal sound perception, and on its conductive and/or sensorineural part.

Objectives To review the literature about acromegaly and hearing loss.

Data Synthesis A systematic literature search was performed using the MEDLINE database, including hand-searching reference lists from original articles. The search was performed using the terms hearing loss and acromegaly, and only 5 studies were found.

Conclusion The results are not consistent, but led to different conclusions. Therefore, more studies with greater numbers of patients with acromegaly are needed.

  • References

  • 1 Melmed S. Acromegaly. N Engl J Med 1990; 322 (14) 966-977
  • 2 Rajasoorya C, Holdaway IM, Wrightson P, Scott DJ, Ibbertson HK. Determinants of clinical outcome and survival in acromegaly. Clin Endocrinol (Oxf) 1994; 41 (01) 95-102
  • 3 Găloiu S, Poiană C. Current therapies and mortality in acromegaly. J Med Life 2015; 8 (04) 411-415
  • 4 CUMMINGS, Charles W, Haughey BH, Thomas JR. et al. Cummings Otolaryngology, Head Neck Surgery. 4th Revised Edition. St. Louis: Elsevier; 2004. . Part fourteen
  • 5 Pekic S, Stojanovic M, Popovic V. Contemporary issues in the evaluation and management of pituitary adenomas. Minerva Endocrinol 2015; 40 (04) 307-319
  • 6 Aydin K, Ozturk B, Turkyilmaz MD. , et al. Functional and structural evaluation of hearing in acromegaly. Clin Endocrinol (Oxf) 2012; 76 (03) 415-419
  • 7 Doig JA, Gatehouse S. Hearing in acromegaly. J Laryngol Otol 1984; 98 (11) 1097-1101
  • 8 Carvalho MA, Montenegro Júnior RM, Freitas MR, Vilar L, Mendonça AT, Montenegro RM. Sensorineural hearing loss in acromegalic patients under treatment. Rev Bras Otorrinolaringol (Engl Ed) 2012; 78 (04) 98-102
  • 9 Graham MD, Brackmann DE. Acromegaly and the temporal bone. J Laryngol Otol 1978; 92 (04) 275-279
  • 10 Babic BB, Petakov MS, Djukic VB. , et al. Conductive hearing loss in patients with active acromegaly. Otol Neurotol 2006; 27 (06) 865-870