Semin Neurol 2017; 37(02): 215-227
DOI: 10.1055/s-0037-1602422
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Recognizing Atypical Parkinsonisms: “Red Flags” and Therapeutic Approaches

Nikolaus R. McFarland
1  Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida College of Medicine, Gainesville, Florida
,
Christopher W. Hess
1  Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida College of Medicine, Gainesville, Florida
› Author Affiliations
Further Information

Publication History

Publication Date:
16 May 2017 (online)

Abstract

The overlap of signs and symptoms between Parkinson's disease and the atypical parkinsonian syndromes, such as progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome and dementia with Lewy bodies, can render clinical diagnoses challenging. The continued evolution of diagnostic criteria to reflect the increasingly recognized heterogeneous presentations of these diseases further complicates timely recognition and diagnosis. In this review, we provide a diagnostic approach to the classic atypical parkinsonian syndromes, with an emphasis on the key clinical and pathological features of each and the recognition of “red flags” in the setting of recent advances in diagnosis and treatment.