CC BY-NC-ND 4.0 · J Neurol Surg Rep 2017; 78(02): e59-e67
DOI: 10.1055/s-0037-1601327
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Treatment of Posttubercular Syringomyelia Not Responsive to Antitubercular Therapy: Case Report and Review of Literature

Giuseppe Canova
1   Department of Neurosurgery, University of Padova, Treviso Regional Hospital, Treviso, Italy
,
Alessandro Boaro
1   Department of Neurosurgery, University of Padova, Treviso Regional Hospital, Treviso, Italy
,
Enrico Giordan
1   Department of Neurosurgery, University of Padova, Treviso Regional Hospital, Treviso, Italy
,
Pierluigi Longatti
1   Department of Neurosurgery, University of Padova, Treviso Regional Hospital, Treviso, Italy
› Author Affiliations
Further Information

Publication History

07 October 2016

18 January 2017

Publication Date:
17 April 2017 (online)

Abstract

Posttubercular adhesive arachnoiditis is a rare, late complication of tubercular meningitis. Syringomyelia can develop as a consequence of intramedullary cystic lesions and cerebrospinal fluid (CSF) flow disturbance around the spinal cord, even after successful chemotherapy. We reviewed the literature related to posttubercular syringomyelia treatment and suggest a new combined surgical approach. A 25-year-old Nigerian male patient presented with legs numbness, urinary disturbance, and legs weakness. Spinal magnetic resonance revealed a T5-T7 syringomyelia, secondary to adhesive spinal arachnoiditis related to a history of tuberculous meningitis. Adhesiolysis by direct visualization with a flexible endoscope was performed and a handmade S-italic syringe-subdural shunt was placed to restore CSF flow. During the postoperative course, the neurological deficits improved together with the resolution of the syrinx. Long-term magnetic resonance imaging follow-up documented no recurrences or shunt displacements. We suggest that, when antitubercular therapy is not effective to resolve postarachnoiditis syrinx, arachnolysis with a flexible endoscope together with the placement of an S-italic shunt allowed free CSF communication between the syrinx and the subarachnoid space. Furthermore, we support that the use of an s-shaped shunt could prevent displacement or migration of the device and allows an easier revision in case of acute or late complications.

Informed Consent

An informed consent was obtained from all individual participants included in the study.


 
  • References

  • 1 Di Lorenzo N, Cacciola F. Adult syringomielia. Classification, pathogenesis and therapeutic approaches. J Neurosurg Sci 2005; 49 (03) 65-72
  • 2 Ersoy Y, Ates O, Onal C. , et al. Cerebellar abscess and syringomyelia due to isoniazid-resistant Mycobacterium tuberculosis. J Clin Neurosci 2007; 14 (01) 86-89
  • 3 Gul S, Celebı G, Kalayci M, Acikgoz B. Syringomyelia and intradural extramedullary tuberculoma of the spinal cord as a late complication of tuberculous meningitis. Turk Neurosurg 2010; 20 (04) 561-565
  • 4 Kaynar MY, Koçer N, Gençosmanoğlu BE, Hanci M. Syringomyelia--as a late complication of tuberculous meningitis. Acta Neurochir (Wien) 2000; 142 (08) 935-938 , discussion 938–939
  • 5 Khalid M, Khalid S, Mittal S, Ahmad U. Intramedullary tubercular abscess with syrinx formation. J Pediatr Neurosci 2012; 7 (01) 61-63
  • 6 Kim SH, Choi SW, Youm JY, Kwon HJ. Syringo-subarachnoid-peritoneal shunt using T-tube for treatment of post-traumatic syringomyelia. J Korean Neurosurg Soc 2012; 52 (01) 58-61
  • 7 Ramanathan SR, Ahluwalia T. Rare complication: Acute syringomyelia due to tuberculoma and tubercular meningitis. J Neurosci Rural Pract 2010; 1 (02) 123-125
  • 8 Sharma B, Nagpal K, Handa R, Gupta P. Intradural extramedullary and intracranial tuberculomas with concurrent communicating syringomyelia. BMJ Case Rep 2014; 2014 (14) bcr2013201368
  • 9 Koyanagi I, Iwasaki Y, Hida K, Houkin K. Clinical features and pathomechanisms of syringomyelia associated with spinal arachnoiditis. Surg Neurol 2005; 63 (04) 350-355 , discussion 355–356
  • 10 Iwatsuki K, Yoshimine T, Ohnishi Y, Ninomiya K, Moriwaki T, Ohkawa T. Syringomyelia associated with spinal arachnoiditis treated by partial arachnoid dissection and syrinx-far distal subarachnoid shunt. Clin Med Insights Case Rep 2014; 7: 107-110
  • 11 Barbaro NM, Wilson CB, Gutin PH, Edwards MS. Surgical treatment of syringomyelia. Favorable results with syringoperitoneal shunting. J Neurosurg 1984; 61 (03) 531-538
  • 12 Ram Z, Findler G, Tadmor R, Sahar A, Shacked I. Syringopleural shunt for the treatment of syringomyelia. Technical note. Spine 1990; 15 (03) 231-233
  • 13 Bhagavathula Venkata SS, Arimappamagan A, Lafazanos S, Pruthi N. Syringomyelia secondary to cervical spondylosis: Case report and review of literature. J Neurosci Rural Pract 2014; 5 (Suppl. 01) S78-S82
  • 14 Brodbelt AR, Stoodley MA. Post-traumatic syringomyelia: a review. J Clin Neurosci 2003; 10 (04) 401-408
  • 15 Makkar G, Srivastava A, Aggarwal AK. Intradural extramedullary spinal tuberculoma-an uncommon entity. Indian J Radiol Imaging 2003; 13: 103-104
  • 16 Maxmauer U, Danz B, Gottschalk A, Kunz U. Endoscope-assisted surgery of spinal intradural adhesions in the presence of cerebrospinal fluid flow obstruction. Spine 2011; 36 (12) E773-E779
  • 17 Muthukumar N, Sureshkumar V. Concurrent syringomyelia and intradural extramedullary tuberculoma as late complications of tuberculous meningitis. J Clin Neurosci 2007; 14 (12) 1225-1230
  • 18 Josephson A, Greitz D, Klason T, Olson L, Spenger C. A spinal thecal sac constriction model supports the theory that induced pressure gradients in the cord cause edema and cyst formation. Neurosurgery 2001; 48 (03) 636-645 , discussion 645–646
  • 19 Isik N, Elmaci I, Isik N. , et al. Long-term results and complications of the syringopleural shunting for treatment of syringomyelia: a clinical study. Br J Neurosurg 2013; 27 (01) 91-99
  • 20 Oluigbo CO, Thacker K, Flint G. The role of lumboperitoneal shunts in the treatment of syringomyelia. J Neurosurg Spine 2010; 13 (01) 133-138
  • 21 Aghakhani N, Baussart B, David P. , et al. Surgical treatment of posttraumatic syringomyelia. Neurosurgery 2010; 66 (06) 1120-1127 , discussion 1127
  • 22 Soo TM, Sandquist L, Tong D, Barrett R. Surgical treatment of idiopathic syringomyelia: Silastic wedge syringosubarachnoid shunting technique. Surg Neurol Int 2014; 5: 114
  • 23 Fan T, Zhao X, Zhao H. , et al. Treatment of selected syringomyelias with syringo-pleural shunt: the experience with a consecutive 26 cases. Clin Neurol Neurosurg 2015; 137: 50-56
  • 24 Colak A, Boran BO, Kutlay M, Demirican N. A modified technique for syringo-subarachnoid shunt for treatment of syringomyelia. J Clin Neurosci 2005; 12 (06) 677-679
  • 25 Cacciola F, Capozza M, Perrini P, Benedetto N, Di Lorenzo N. Syringopleural shunt as a rescue procedure in patients with syringomyelia refractory to restoration of cerebrospinal fluid flow. Neurosurgery 2009; 65 (03) 471-476 , discussion 476
  • 26 Lund-Johansen M, Wester K. Syringomyelia treated with a nonvalved syringoperitoneal shunt: a follow-up study. Neurosurgery 1997; 41 (04) 858-864 , discussion 864–865
  • 27 Ghobrial GM, Dalyai RT, Maltenfort MG, Prasad SK, Harrop JS, Sharan AD. Arachnolysis or cerebrospinal fluid diversion for adult-onset syringomyelia? A Systematic review of the literature. World Neurosurg 2015; 83 (05) 829-835
  • 28 Ohata K, Gotoh T, Matsusaka Y. , et al. Surgical management of syringomyelia associated with spinal adhesive arachnoiditis. J Clin Neurosci 2001; 8 (01) 40-42
  • 29 Klekamp J. Treatment of posttraumatic syringomyelia. J Neurosurg Spine 2012; 17 (03) 199-211
  • 30 Caplan LR, Norohna AB, Amico LL. Syringomyelia and arachnoiditis. J Neurol Neurosurg Psychiatry 1990; 53 (02) 106-113
  • 31 Eguchi T, Tamaki N, Kurata H. Endoscopy of the spinal cord: cadaveric study and clinical experience. Minim Invasive Neurosurg 1999; 42 (03) 146-151
  • 32 Huewel N, Perneczky A, Urban V, Fries G. Neuroendoscopic technique for the operative treatment of septated syringomyelia. Acta Neurochir Suppl (Wien) 1992; 54: 59-62
  • 33 Mauer UM, Gottschalk A, Kunz U, Schulz C. Arachnoscopy: a special application of spinal intradural endoscopy. Neurosurg Focus 2011; 30 (04) E7
  • 34 Endo T, Takahashi T, Jokura H, Tominaga T. Surgical treatment of spinal intradural arachnoid cysts using endoscopy. J Neurosurg Spine 2010; 12 (06) 641-646