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DOI: 10.1055/s-0037-1601327
Treatment of Posttubercular Syringomyelia Not Responsive to Antitubercular Therapy: Case Report and Review of Literature
Publication History
07 October 2016
18 January 2017
Publication Date:
17 April 2017 (online)

Abstract
Posttubercular adhesive arachnoiditis is a rare, late complication of tubercular meningitis. Syringomyelia can develop as a consequence of intramedullary cystic lesions and cerebrospinal fluid (CSF) flow disturbance around the spinal cord, even after successful chemotherapy. We reviewed the literature related to posttubercular syringomyelia treatment and suggest a new combined surgical approach. A 25-year-old Nigerian male patient presented with legs numbness, urinary disturbance, and legs weakness. Spinal magnetic resonance revealed a T5-T7 syringomyelia, secondary to adhesive spinal arachnoiditis related to a history of tuberculous meningitis. Adhesiolysis by direct visualization with a flexible endoscope was performed and a handmade S-italic syringe-subdural shunt was placed to restore CSF flow. During the postoperative course, the neurological deficits improved together with the resolution of the syrinx. Long-term magnetic resonance imaging follow-up documented no recurrences or shunt displacements. We suggest that, when antitubercular therapy is not effective to resolve postarachnoiditis syrinx, arachnolysis with a flexible endoscope together with the placement of an S-italic shunt allowed free CSF communication between the syrinx and the subarachnoid space. Furthermore, we support that the use of an s-shaped shunt could prevent displacement or migration of the device and allows an easier revision in case of acute or late complications.
Keywords
posttubercular complication - syringomyelia - arachnoiditis - spinal shunt - flexible endoscopyInformed Consent
An informed consent was obtained from all individual participants included in the study.
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References
- 1 Di Lorenzo N, Cacciola F. Adult syringomielia. Classification, pathogenesis and therapeutic approaches. J Neurosurg Sci 2005; 49 (03) 65-72
- 2 Ersoy Y, Ates O, Onal C. , et al. Cerebellar abscess and syringomyelia due to isoniazid-resistant Mycobacterium tuberculosis. J Clin Neurosci 2007; 14 (01) 86-89
- 3 Gul S, Celebı G, Kalayci M, Acikgoz B. Syringomyelia and intradural extramedullary tuberculoma of the spinal cord as a late complication of tuberculous meningitis. Turk Neurosurg 2010; 20 (04) 561-565
- 4 Kaynar MY, Koçer N, Gençosmanoğlu BE, Hanci M. Syringomyelia--as a late complication of tuberculous meningitis. Acta Neurochir (Wien) 2000; 142 (08) 935-938 , discussion 938–939
- 5 Khalid M, Khalid S, Mittal S, Ahmad U. Intramedullary tubercular abscess with syrinx formation. J Pediatr Neurosci 2012; 7 (01) 61-63
- 6 Kim SH, Choi SW, Youm JY, Kwon HJ. Syringo-subarachnoid-peritoneal shunt using T-tube for treatment of post-traumatic syringomyelia. J Korean Neurosurg Soc 2012; 52 (01) 58-61
- 7 Ramanathan SR, Ahluwalia T. Rare complication: Acute syringomyelia due to tuberculoma and tubercular meningitis. J Neurosci Rural Pract 2010; 1 (02) 123-125
- 8 Sharma B, Nagpal K, Handa R, Gupta P. Intradural extramedullary and intracranial tuberculomas with concurrent communicating syringomyelia. BMJ Case Rep 2014; 2014 (14) bcr2013201368
- 9 Koyanagi I, Iwasaki Y, Hida K, Houkin K. Clinical features and pathomechanisms of syringomyelia associated with spinal arachnoiditis. Surg Neurol 2005; 63 (04) 350-355 , discussion 355–356
- 10 Iwatsuki K, Yoshimine T, Ohnishi Y, Ninomiya K, Moriwaki T, Ohkawa T. Syringomyelia associated with spinal arachnoiditis treated by partial arachnoid dissection and syrinx-far distal subarachnoid shunt. Clin Med Insights Case Rep 2014; 7: 107-110
- 11 Barbaro NM, Wilson CB, Gutin PH, Edwards MS. Surgical treatment of syringomyelia. Favorable results with syringoperitoneal shunting. J Neurosurg 1984; 61 (03) 531-538
- 12 Ram Z, Findler G, Tadmor R, Sahar A, Shacked I. Syringopleural shunt for the treatment of syringomyelia. Technical note. Spine 1990; 15 (03) 231-233
- 13 Bhagavathula Venkata SS, Arimappamagan A, Lafazanos S, Pruthi N. Syringomyelia secondary to cervical spondylosis: Case report and review of literature. J Neurosci Rural Pract 2014; 5 (Suppl. 01) S78-S82
- 14 Brodbelt AR, Stoodley MA. Post-traumatic syringomyelia: a review. J Clin Neurosci 2003; 10 (04) 401-408
- 15 Makkar G, Srivastava A, Aggarwal AK. Intradural extramedullary spinal tuberculoma-an uncommon entity. Indian J Radiol Imaging 2003; 13: 103-104
- 16 Maxmauer U, Danz B, Gottschalk A, Kunz U. Endoscope-assisted surgery of spinal intradural adhesions in the presence of cerebrospinal fluid flow obstruction. Spine 2011; 36 (12) E773-E779
- 17 Muthukumar N, Sureshkumar V. Concurrent syringomyelia and intradural extramedullary tuberculoma as late complications of tuberculous meningitis. J Clin Neurosci 2007; 14 (12) 1225-1230
- 18 Josephson A, Greitz D, Klason T, Olson L, Spenger C. A spinal thecal sac constriction model supports the theory that induced pressure gradients in the cord cause edema and cyst formation. Neurosurgery 2001; 48 (03) 636-645 , discussion 645–646
- 19 Isik N, Elmaci I, Isik N. , et al. Long-term results and complications of the syringopleural shunting for treatment of syringomyelia: a clinical study. Br J Neurosurg 2013; 27 (01) 91-99
- 20 Oluigbo CO, Thacker K, Flint G. The role of lumboperitoneal shunts in the treatment of syringomyelia. J Neurosurg Spine 2010; 13 (01) 133-138
- 21 Aghakhani N, Baussart B, David P. , et al. Surgical treatment of posttraumatic syringomyelia. Neurosurgery 2010; 66 (06) 1120-1127 , discussion 1127
- 22 Soo TM, Sandquist L, Tong D, Barrett R. Surgical treatment of idiopathic syringomyelia: Silastic wedge syringosubarachnoid shunting technique. Surg Neurol Int 2014; 5: 114
- 23 Fan T, Zhao X, Zhao H. , et al. Treatment of selected syringomyelias with syringo-pleural shunt: the experience with a consecutive 26 cases. Clin Neurol Neurosurg 2015; 137: 50-56
- 24 Colak A, Boran BO, Kutlay M, Demirican N. A modified technique for syringo-subarachnoid shunt for treatment of syringomyelia. J Clin Neurosci 2005; 12 (06) 677-679
- 25 Cacciola F, Capozza M, Perrini P, Benedetto N, Di Lorenzo N. Syringopleural shunt as a rescue procedure in patients with syringomyelia refractory to restoration of cerebrospinal fluid flow. Neurosurgery 2009; 65 (03) 471-476 , discussion 476
- 26 Lund-Johansen M, Wester K. Syringomyelia treated with a nonvalved syringoperitoneal shunt: a follow-up study. Neurosurgery 1997; 41 (04) 858-864 , discussion 864–865
- 27 Ghobrial GM, Dalyai RT, Maltenfort MG, Prasad SK, Harrop JS, Sharan AD. Arachnolysis or cerebrospinal fluid diversion for adult-onset syringomyelia? A Systematic review of the literature. World Neurosurg 2015; 83 (05) 829-835
- 28 Ohata K, Gotoh T, Matsusaka Y. , et al. Surgical management of syringomyelia associated with spinal adhesive arachnoiditis. J Clin Neurosci 2001; 8 (01) 40-42
- 29 Klekamp J. Treatment of posttraumatic syringomyelia. J Neurosurg Spine 2012; 17 (03) 199-211
- 30 Caplan LR, Norohna AB, Amico LL. Syringomyelia and arachnoiditis. J Neurol Neurosurg Psychiatry 1990; 53 (02) 106-113
- 31 Eguchi T, Tamaki N, Kurata H. Endoscopy of the spinal cord: cadaveric study and clinical experience. Minim Invasive Neurosurg 1999; 42 (03) 146-151
- 32 Huewel N, Perneczky A, Urban V, Fries G. Neuroendoscopic technique for the operative treatment of septated syringomyelia. Acta Neurochir Suppl (Wien) 1992; 54: 59-62
- 33 Mauer UM, Gottschalk A, Kunz U, Schulz C. Arachnoscopy: a special application of spinal intradural endoscopy. Neurosurg Focus 2011; 30 (04) E7
- 34 Endo T, Takahashi T, Jokura H, Tominaga T. Surgical treatment of spinal intradural arachnoid cysts using endoscopy. J Neurosurg Spine 2010; 12 (06) 641-646