Treatment of Cheyne-Stokes respiration in patients with heart failure with reduced ejection fraction – Registry

Patients with chronic heart failure despite reduced left ventricular ejection fraction (HFREF) with evidence of moderate to severe Cheyne-Stokes-Respiration (CSA) on polysomnography or polygraphy shall be included into a prospective registry and followed-up for at least 24 months irrespective of treatment strategy. Baseline data includes demographic and medical history, questionnaires (Epworth Sleepiness Scale, Kansas City Cardiomyopathy Questionnaire), diagnostic cardiorespiratory polygraphy/polysomnography and cardiorespiratory polygraphy/polysomnography during therapy, cardiopulmonary exercise testing and/or 6-minute walk test, and echocardiography, Patients will be followed-up every 6 months by telephone for the documentation of adverse and severe adverse events, as well as after 12 and 24 months for changes in cardiopulmonary function (echocardiography (mandatory), cardiopulmonary exercise testing and/or 6-minute walk test as well as cardiorespiratory polygraphy or polysomnography (if available))..

Data will be compared between different treatment strategies for the primary as well as the secondary endpoints.