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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2017; 21(03): 265-269
DOI: 10.1055/s-0037-1599061
Original Research
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Relationship of Tumor Thickness with Neck Node Metastasis in Buccal Squamous Cell Carcinoma: An Experience at a Tertiary Care Hospital

Sadaf Qadeer Ahmed
1   Department of Otorhinolaryngology, Sir Syed College of Medical Sciences for Girls Ringgold Standard Institution, Karachi, Pakistan
,
Montasir Junaid
2   Department of Otorhinolaryngology, Jinnah Medical and Dental College Ringgold Standard Institution, Karachi, Pakistan
,
Sohail Awan
3   Department of Otorhinolaryngology, Aga Khan University Ringgold Standard Institution, Karachi, Pakistan
,
Moaz M. Choudhary
4   Department of Medicine, Aga Khan University Ringgold Standard Institution, Karachi, Pakistan
,
Maliha Kazi
5   Department of Otorhinolaryngology, Manchester Royal Infirmary, Manchester, United Kingdom
,
Aria Masoom
6   Department of Otorhinolaryngology, Bolan Medical College Ringgold Standard Institution, Quetta, Pakistan
,
Hareem Usman Khan
7   Department of Medicine, Shifa College of Medicine Ringgold Standard Institution, Islamabad, Pakistan
› Author Affiliations
Further Information

Publication History

23 July 2016

15 January 2017

Publication Date:
21 February 2017 (online)

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Abstract

Introduction Squamous cell carcinoma is the most common malignancy of the head and neck, with the buccal mucosa being the most common site involved. Early locoregional metastasis is a hallmark of this disease, and early stage tumors may harbor metastatic nodes that are occult. Certain parameters can help identify high-risk patients for whom the pattern of occult nodal metastasis can be predicted. Tumor thickness is one such objective parameter.

Objective To determine the relationship of tumor thickness with neck node metastasis in squamous cell carcinoma of the buccal mucosa.

Methods A retrospective chart review of 102 patients with biopsy-proven squamous cell carcinoma of the buccal mucosa with N0 Necks was performed. All patients underwent tumor resection with neck dissection, and the tumor thickness was measured. Univariate and multivariate analyses were performed.

Results A total of 102 patients, of which 73.53% were males and 26.47% were females. The mean age of the patients was 49.3 ± 11.1 years. It was found that the risk of neck node metastasis in buccal squamous cell carcinoma increases 35.5 times for a tumor thickness ≥ 2 mm, and the risk of neck node metastasis in buccal squamous cell carcinoma decreases by 0.58 times for each centimeter decrease in tumor size, while the rate of occult neck lymph node metastasis was found to be 37%.

Conclusion We conclude that tumor thickness is significantly related with neck nodal metastasis in buccal squamous cell carcinoma, considering the age of the patient and the size of the tumor.

Keywords

buccal mucosa - squamous cell carcinoma - metastasis
 

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