Clinical Features and Surgical Treatment of Schwannoma Affecting the Base of the Tongue: A Systematic Review
11 August 2016
21 December 2016
13 February 2017 (eFirst)
Introduction Schwannomas of the head and neck account for 25–40% of all cases, with presentation at the base of the tongue as the most frequent site for intraoral tumors.
Objectives Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the tongue.
Data Synthesis Most patients presented with a single, painless, well-encapsulated nodule at the base of the tongue. These nodules were slow-growing, with an average of 13.3 months from onset to presentation. Most cases were accompanied by airway obstruction, indicated by symptoms of dysphagia, dysarthria, snoring, and sleep apnea. Overall, the histological studies were consistent with a benign schwannoma with a palisading Antoni A and Antoni B pattern without malignant changes in cell morphology. These tumors were treated via complete surgical excision, and all cases achieved full remission by final follow-up.
Conclusion Surgical removal is the primary mode of treatment with excellent postoperative prognosis and rare instances of recurrence. Given the rarity of this tumor, this review of available case studies serves to comprehensively describe clinical presentation and surgical treatment approaches to tongue base schwannoma.
- 1 Batra UB, Usha G, Gogia AR. Anesthetic management of schwannoma of the base of the tongue. J Anaesthesiol Clin Pharmacol 2011; 27 (02) 241-243
- 2 George NA, Wagh M, Balagopal PG, Gupta S, Sukumaran R, Sebastian P. Schwannoma base tongue: Case report and review of literature. Gulf J Oncolog 2014; 1 (16) 94-100
- 3 Spandow O, Fagerlund M, Bergmark L, Boquist L. Clinical and histopathological features of a large parapharyngeal neurilemmoma located at the base of the tongue. ORL J Otorhinolaryngol Relat Spec 1999; 61 (01) 25-30
- 4 Pereira LJ, Pereira PP, dos Santos JdeP, Reis Filho VF, Dominguete PR, Pereira AA. Lingual schwannoma involving the posterior lateral border of the tongue in a young individual: case report. J Clin Pediatr Dent 2008; 33 (01) 59-62
- 5 Ballesteros F, Vilaseca I, Blanch JL, Gaspa A, Bernal-Sprekelsen M. Base of tongue neurilemmoma: excision by transoral laser microsurgery. Acta Otolaryngol 2007; 127 (09) 1005-1007
- 6 Singh GB, Arora R, Garg S, Aggarwal K. Base of tongue schwannoma. ENT - Ear, Nose & Throat Journal 2015; 306-308
- 7 Mehrzad H, Persaud R, Papadimitriou N, Kaniyur S, Mochloulis G. Schwannoma of tongue base treated with transoral carbon dioxide laser. Lasers Med Sci 2006; 21 (04) 235-237
- 8 Sharma S, Rai G. Schwannoma (neurilemmoma) on the base of the tongue: a rare clinical case. Am J Case Rep 2016; 17: 203-206
- 9 Ying YL, Zimmer LA, Myers EN. Base of tongue schwannoma: a case report. Laryngoscope 2006; 116 (07) 1284-1287
- 10 de Bree R, Westerveld GJ, Smeele LE. Submandibular approach for excision of a large schwannoma in the base of the tongue. Eur Arch Otorhinolaryngol 2000; 257 (05) 283-286
- 11 Sawhney R, Carron MA, Mathog RH. Tongue base schwannoma: report, review, and unique surgical approach. Am J Otolaryngol 2008; 29 (02) 119-122
- 12 Bassichis BA, McClay JE. Pedunculated neurilemmoma of the tongue base. Otolaryngol Head Neck Surg 2004; 130 (05) 639-641
- 13 Hsu YC, Hwang CF, Hsu RF, Kuo FY, Chien CY. Schwannoma (neurilemmoma) of the tongue. Acta Otolaryngol 2006; 126 (08) 861-865
- 14 Ying B, Zhu S, Qiao Y. , et al. Surgical approaches for tongue base schwannoma. J Craniofac Surg 2013; 24 (01) e9-e11
- 15 Badar Z, Farooq Z, Zaccarini D, Ezhapilli SR. Tongue base schwannoma: differential diagnosis and imaging features with a case presentation. Radiol Case Rep 2016; 11 (04) 336-340