Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience

Daniel V. Wakefield; Garrett T. Venable; Noam A. VanderWalde; L. Madison Michael II; Jeffery M. Sorenson; Jon H. Robertson; David Cunninghan; Matthew T. Ballo

doi:10.1055/s-0036-1597986

Journal of Neurological Surgery Part B: Skull Base, Inhaltsverzeichnis

J Neurol Surg B Skull Base 2017; 78(03): 251-255
DOI: 10.1055/s-0036-1597986

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience

Authors

Daniel V. Wakefield

¹Department of Radiation Oncology, University of Tennessee Health Science Center, Memphis, Tennessee, United States
Garrett T. Venable

²Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, United States
Noam A. VanderWalde

¹Department of Radiation Oncology, University of Tennessee Health Science Center, Memphis, Tennessee, United States

³West Cancer Center, Memphis, Tennessee, United States
L. Madison Michael II

²Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, United States

⁴Semmes-Murphey Clinic, Memphis, Tennessee, United States

⁵Memphis Regional Gamma Knife Center, Memphis, Tennessee, United States
Jeffery M. Sorenson

²Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, United States

⁴Semmes-Murphey Clinic, Memphis, Tennessee, United States

⁵Memphis Regional Gamma Knife Center, Memphis, Tennessee, United States
Jon H. Robertson

²Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, United States

⁴Semmes-Murphey Clinic, Memphis, Tennessee, United States

⁵Memphis Regional Gamma Knife Center, Memphis, Tennessee, United States
David Cunninghan

²Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, United States

⁴Semmes-Murphey Clinic, Memphis, Tennessee, United States

⁵Memphis Regional Gamma Knife Center, Memphis, Tennessee, United States
Matthew T. Ballo

¹Department of Radiation Oncology, University of Tennessee Health Science Center, Memphis, Tennessee, United States

³West Cancer Center, Memphis, Tennessee, United States

Abstract

Objective This case series investigates management of glomus jugulare (GJ) tumors utilizing definitive and salvage Gamma Knife stereotactic radiosurgery (GKSRS).

Methods A retrospective chart review was performed to collect data. Statistical analysis included patient, tumor, and treatment information.

Results From 1996 to 2013, 17 patients with GJ received GKSRS. Median age was 64 years (range, 27–76). GKSRS was delivered for definitive treatment in eight (47%) and salvage in nine (53%) patients. Median tumor volume was 9.8 cm³ (range, 2.8–42 cm³). Median dose was 15 Gy (range, 13–18 Gy). Median follow-up was 123 months (range, 38–238 months). Tumor size decreased in 10 (59%), stabilized in 6 (35%), and increased in 1 patient (6%). Overall neurological deficit improved in 53%, stabilized in 41%, and worsened in 6% of patients. Overall cause-specific survival was 100%, and actuarial local control was 94%. Eighty-eight percent of patients without prior resection experienced neurologic deficit improvement, while 25% of patients with prior resection experienced neurologic improvement (p = 0.02).

Conclusion Gamma Knife radiosurgery provides effective long-term control of GJ and overall improvement or stabilization of neurological deficit in most patients. Patients with prior resection are less likely to experience improvement of neurologic deficit.

Keywords

glomus jugulare - Gamma Knife - radiosurgery - salvage

Volltext

Referenzen

References
1 Moffat DA, Hardy DG. Surgical management of large glomus jugulare tumours: infra- and trans-temporal approach. J Laryngol Otol 1989; 103 (12) 1167-1180
2 Al-Mefty O, Teixeira A. Complex tumors of the glomus jugulare: criteria, treatment, and outcome. J Neurosurg 2002; 97 (06) 1356-1366
3 Michael II LM, Robertson JH. Glomus jugulare tumors: historical overview of the management of this disease. Neurosurg Focus 2004; 17 (02) E1
4 Tomasello F, Conti A. Judicious management of jugular foramen tumors. World Neurosurg 2015; 83 (05) 756-757
5 Arthur K. Radiotheraphy in chemodectoma of the glomus jugulare. Clin Radiol 1977; 28 (04) 415-417
6 Foote RL, Coffey RJ, Gorman DA. , et al. Stereotactic radiosurgery for glomus jugulare tumors: a preliminary report. Int J Radiat Oncol Biol Phys 1997; 38 (03) 491-495
7 Gottfried ON, Liu JK, Couldwell WT. Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors. Neurosurg Focus 2004; 17 (02) E4
8 Ivan ME, Sughrue ME, Clark AJ. , et al. A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors. J Neurosurg 2011; 114 (05) 1299-1305
9 Larouere MJ, Zappia JJ, Wilner HI, Graham MD, Lundy LB. Selective embolization of glomus jugulare tumors. Skull Base Surg 1994; 4 (01) 21-25
10 Suárez C, Rodrigo JP, Bödeker CC. , et al. Jugular and vagal paragangliomas: Systematic study of management with surgery and radiotherapy. Head Neck 2013; 35 (08) 1195-1204
11 McCabe BF, Fletcher M. Selection of therapy of glomus jugulare tumors. Arch Otolaryngol 1969; 89 (01) 156-159
12 Pareschi R, Righini S, Destito D, Raucci AF, Colombo S. Surgery of Glomus Jugulare Tumors. Skull Base 2003; 13 (03) 149-157
13 Ramina R, Maniglia JJ, Fernandes YB, Paschoal JR, Pfeilsticker LN, Coelho Neto M. Tumors of the jugular foramen: diagnosis and management. Neurosurgery 2005; 57 (1, Suppl): 59-68 , discussion 59–68
14 Patel SJ, Sekhar LN, Cass SP, Hirsch BE. Combined approaches for resection of extensive glomus jugulare tumors. A review of 12 cases. J Neurosurg 1994; 80 (06) 1026-1038
15 Lope Ahmad RA, Sivalingam S, Konishi M, De Donato G, Sanna M. Oncologic outcome in surgical management of jugular paraganglioma and factors influencing outcomes. Head Neck 2013; 35 (04) 527-534
16 Guss ZD, Batra S, Limb CJ. , et al. Radiosurgery of glomus jugulare tumors: a meta-analysis. Int J Radiat Oncol Biol Phys 2011; 81 (04) e497-e502
17 Gilbo P, Morris CG, Amdur RJ. , et al. Radiotherapy for benign head and neck paragangliomas: a 45-year experience. Cancer 2014; 120 (23) 3738-3743
18 El Majdoub F, Hunsche S, Igressa A, Kocher M, Sturm V, Maarouf M. Stereotactic LINAC-radiosurgery for glomus jugulare tumors: a long-term follow-up of 27 patients. PLoS One 2015; 10 (06) e0129057
19 Gandía-González ML, Kusak ME, Moreno NM, Sárraga JG, Rey G, Álvarez RM. Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases. J Neurosurg 2014; 121 (05) 1158-1165
20 Carlson ML, Sweeney AD, Wanna GB, Netterville JL, Haynes DS. Natural history of glomus jugulare: a review of 16 tumors managed with primary observation. Otolaryngol Head Neck Surg 2015; 152 (01) 98-105
21 Wang ML, Hussey DH, Doornbos JF, Vigliotti AP, Wen BC. Chemodectoma of the temporal bone: a comparison of surgical and radiotherapeutic results. Int J Radiat Oncol Biol Phys 1988; 14 (04) 643-648
22 Moore GR, Robbins JP, Seale DL, Fitz-Hugh GS, Constable WC. Chemodectomas of the middle ear. A comparison of therapeutic modalities. Arch Otolaryngol 1973; 98 (05) 330-335
23 Wong BJ, Roos DE, Borg MF. Glomus jugulare tumours: a 15 year radiotherapy experience in South Australia. J Clin Neurosci 2014; 21 (03) 456-461
24 Liscak R, Urgosik D, Chytka T. , et al. Leksell Gamma Knife radiosurgery of the jugulotympanic glomus tumor: long-term results. J Neurosurg 2014; 121 (Suppl): 198-202
25 Schuster D, Sweeney AD, Stavas MJ. , et al. Initial radiographic tumor control is similar following single or multi-fractionated stereotactic radiosurgery for jugular paragangliomas. Am J Otolaryngol 2016; 37 (03) 255-258
26 Sager O, Dincoglan F, Beyzadeoglu M. Stereotactic radiosurgery of glomus jugulare tumors: current concepts, recent advances and future perspectives. CNS Oncol 2015; 4 (02) 105-114