J Pediatr Neuroradiol 2016; 05(04): 248-252
DOI: 10.1055/s-0036-1597687
Original Article
Georg Thieme Verlag KG Stuttgart • New York

Influence of Oxygen Saturation and Age on Relaxation Time of Gray and White Matter and Diffusion Tensor Imaging Parameters in Children with Cardiac Malformations

Juan Leon-Wyss1, Bernd Foerster2, Cynthia Rosario1, Janet Toribio1, Herwin Speckter2, Jairo Oviedo2, Peter Stoeter2
  • 1Cardiovascular Center, CEDIMAT, Santo Domingo, Dominican Republic
  • 2Department of Radiology, CEDIMAT, Santo Domingo, Dominican Republic
Further Information

Publication History

13 November 2016

26 November 2016

Publication Date:
26 December 2016 (eFirst)


The aim of this article is to investigate the influence of reduced arterial oxygenation on cerebral gray and white matter T2* time and parameters of diffusion tensor imaging (DTI) in children with cardiac malformations. In 23 patients examined by magnetic resonance imaging (3T), parameters were correlated to oxygen saturation and age (regression analysis). Reduced oxygen saturation correlated significantly to gray matter T2* time (p ≤ 0.01), whereas fractional anisotropy, mean diffusivity, and radial diffusivity correlated to age (p ≤ 0.005) but not to oxygenation. To conclude, gray matter T2* time might be used as a surrogate parameter to estimate oxygenation, and oxygenation does not influence the evaluation of DTI parameters.