Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596481
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

In vitro antibacterial activity of Vernonia polyanthes Less. leaf rinse extract (Asteraceae): prospecting new therapeutic options against Staphylococcus aureus infections!

JDG de Santana
1   Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
,
JR Florêncio
1   Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
,
LMS de Almeida
1   Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
,
LS Fernandes
2   Pharmacy Course, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
,
AA da Silva Filho
3   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
,
MJ Salvador
4   Department of Vegetable Biology, Biology Institute, Universidade Estadual de Campinas, Rua Monteiro Lobato, 255, CEP 13083 – 862, Campinas, Brazil
,
OV Sousa
3   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
,
MS Alves
3   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, São Pedro, CEP 36036 – 900, Juiz de Fora, Brazil
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

 

Vernonia polyanthes Less. (Asteraceae), popularly known as "assa-peixe", is a native vegetal species of South America, especially in Brazil [1]. This medicinal plant is traditionally used in cases of cold, flu, cough, fever, bronchitis and pneumonia [2]. Anatomically, V. polyanthes presents glandular trichomes, which are modified epidermal hairs that contain specialized cells involved in the biosynthesis, storage and secretion of a number of natural molecules, including secondary metabolites [1,3]. Flavonoids and sesquiterpene lactones are considered chemical markers of the Vernonia genus [4]. The current study investigated the in vitro antibacterial activity of V. polyanthes leaf rinse extract (Vp-LRE) in order to corroborate with the traditional use of this plant species and its potential as a source of new antibacterial agents. In vitro antibacterial activity was established by the Minimal Inhibitory Concentration (MIC) using the microdilution method according to the Clinical Laboratory Standards Institute (CLSI) guidelines [5] followed by the Minimal Bactericidal Concentration (MBC), which allows classification of the antibacterial effect as bacteriostatic or bactericidal [6]. Staphylococcus aureus ATCC® 6538™ and ATCC® 29213™, Escherichia coli ATCC® 10536™ and ATCC® 25922™, Salmonella enterica subsp. enterica serovar Choleraesuis ATCC® 10708™, Salmonella enterica subsp. enterica serovar Thyphimurium ATCC® 13311™ and Pseudomonas aeruginosa ATCC® 9027™ and ATCC® 27853™ were used as reference strains. Vp-LRE revealed antibacterial activity against 5 of 8 tested strains, being more active against S. aureus ATCC® 6538™ and ATCC® 29213™ with MIC values of 625 µg/mL for both, demonstrating bacteriostatic effect and MBC of 2500 µg/mL and 1250 µg/mL, respectively. These results suggest the potential of V. polyanthes as a promising source of bioactive molecules with antibacterial action, prospecting new therapeutic approaches against S. aureus infections.

Acknowledgements: This investigation was financially supported by UFJF, FAPEMIG, CNPq and CAPES.

Keywords: Vernonia polyanthes, Asteraceae, glandular trichomes, antibacterial agents, Staphylococcus aureus.

References:

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