Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596457
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

A phytochemical study of two endemic Greek Boraginaceae plants

T Tufa
1   Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, 15771, Athens, Greece
,
H Damianakos
1   Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, 15771, Athens, Greece
,
K Graikou
1   Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, 15771, Athens, Greece
,
I Chinou
1   Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Zografou, 15771, Athens, Greece
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

 

Boraginaceae is a plant family which comprises of approx 130 genera and 2300 species, occurring mainly in Europe and Asia, well known as source of red dyes (e.g. alkanet), or for their pharmaceutical properties. Among the most characteristic secondary metabolites of Boraginaceae are alkannins/shikonins and related isohexenylnaphthazarins, well-known lipophilic red pigments mainly found in their roots, showing significant biological activities such as wound healing, antimicrobial, anti-inflammatory, antioxidant etc. [1, 2]. In the framework of our studies on Boraginaceae plants [3, 4], we present herein, some constituents isolated from the endemic Greek species Alkanna sfikasiana Tan, Vold and Strid and Onosma graeca Boiss. & Spuner, which to our knowledge, have not been studied phytochemically before. From the roots and the aerial parts of A. sfikasiana were isolated two naphthoquinones: isobutyrylalkannin and α-methylbutyrylalkannin, together with lanosterol, linoleic acid, rosmarinic acid, quercetin 3-O-rutinoside and quercetin 3-O-glucoside. The roots of O. graeca afforded four naphthoquinones: deoxyshikonin, β-hydroxyisovalerylalkannin, propionylalkannin and acetylalkannin, as well as β-sitosterol and an isoferulic acid ester.

Keywords: Boraginaceae, Alkanna sfikasiana, Onosma graeca, alkannins/shikonins, flavonoids.

References:

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