Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596439
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Chemical constituents from Houttuynia cordata

J Ahn
1   College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea
,
J Kim
1   College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

 

Houttuynia cordata Thunb. (Saururaceae) is traditionally used as a medicinal plant for treatment of inflammation-related disorders [1] and protection against oxidative stress in Asian countries [2]. The aerial parts of H. cordata contain various types of flavonoids and some alkaloids [3]. Twenty compounds were isolated from H. cordata using chromatographic and semi-preparative HPLC techniques, and found to be two harmala alkaloids, one phenolic acid, four chlorogenic acid derivatives, three phenolic glycosides, two phenylpropanoids derivatives and eight flavonoids. Chemical structures of these compounds were characterized by spectroscopic methods as 3a,12a-dihydro-2H-furo[3,2-b]indolo[3,2,1-ij][1,5]naphthyridine-1,1(4H)-diol (1), perlolyrine (2), 4-hydroxycinnamic acid (3), neochlorogenic acid (4), neochlorogenic acid methyl ester (5), cryptocholorogenic acid (6), cryptochlorogenic acid methyl ester (7), benzyl-β-D-glucoside (8), β-phenylethoxy-β-D-glucopyranoside (9), dopaol-β-D-glucoside (10), guaiacylglycerol (11), (+)-(7S,8S)-guaiacylglycerol-8-O-β-D-glucopyranoside (12), luteolin (13), quercetin (14), apigenin (15), afzelin (16), quercitrin (17), hyperoside (18), kaempferol-3-O-α-L-rhamnosyl-7-O-β-D-glucoside (19) and quercetin-3-O-α-L-rhamnosyl-7-O-β-D-glucoside (20). Among them, compound 1 was isolated from nature for the first time. Compounds 2, 7, 9, 11, 12 and 19 are newly reported from H. cordata.

Keywords: Houttuynia cordata, harmala alkaloid, flavonoids.

References:

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