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DOI: 10.1055/s-0036-1596423
Chemical constituents from Cordia alliodora and Cordia colloccoca from Panama and their antimicrobial and cytotoxic activities
Publication History
Publication Date:
14 December 2016 (online)
The Boraginaceae plant Cordia alliodora (Ruiz and Pavón) Oken, is the most widespread species of the Cordia genus, used in the traditional medicine of Mexico and Caribbean Islands [1]. So far, only the plant leaves [2], heartwood [3, 4] and root bark (dichloromethane extract) of C. alliodora [1] have been studied. From the methanolic extract of C. alliodora root bark the new secondary metabolites: 5-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with the known compounds allantoin (3), N-carbamoylputrescine (4), rosmarinic acid (5) and canthoside C (6), were isolated. Compounds 4 and 6 are reported for the first time within the Boraginaceae family. Furthermore, the methanolic extract of Cordia colloccoca leaves, afforded the known flavonoids afzelin (7) and quercitrin (8). All isolated compounds were assayed for their antimicrobial activities against a panel of six Gram positive and Gram negative bacteria and three human pathogenic fungi, where 4 appeared as the most active (MIC values 2.75 10-3- 2.90 10-3 mg/ml against Gram +, up to 4.20 10-3 mg/ml against Gram – and 3.00 10-3-3.55 10-3 mg/mL against fungi), followed by 1 and 2 (MIC 2.80·10-3 – 5.80·10-3 mg/ml), while all tested metabolites followed a ranking as: 4 > 1 > 2 > 7 > 8 > 5 > 6. All of them were also tested for their cytotoxic activities against two lung cancer cell lines, A549 and NSCLC-N6 (adenocarcinoma and epidermoid lung cancer) where 7 appeared as the most active (IC50 6.7 and 12.9 µg/ml, respectively), followed by 5 (12.7 µg/ml).
Keywords: Cordia alliodora, Cordia colloccoca, Boraginaceae.
References:
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