Planta Med 2016; 82(S 01): S1-S381
DOI: 10.1055/s-0036-1596402
Abstracts
Georg Thieme Verlag KG Stuttgart · New York

Secondary metabolites isolated from Xanthoria parietina (L.) Th. Fr. lichen and their biological activity

G Łaska
1   Department of Environmental Protection and Management, 45A Wiejska Str., 15 – 351 Bialystok, Poland
,
S Kiercul
1   Department of Environmental Protection and Management, 45A Wiejska Str., 15 – 351 Bialystok, Poland
,
A Piotrowska-Niczyporuk
2   Department of Plant Biochemistry and Toxicology, University of Bialystok, 1J Ciolkowskiego Str., 15 – 245 Bialystok, Poland
,
M Jacob
3   National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, United States
,
D Pasco
4   National Center for Natural Product Research Director, UMMC/NCNPR Cancer Drug Discovery Core School of Pharmacy University of Mississippi
› Author Affiliations
Further Information

Publication History

Publication Date:
14 December 2016 (online)

 

To date, approximately 1050 secondary lichen compounds have been identified. These substances are produced primarily by mycobiont and are deposited on the lichen hyphae [1]. Numerous experiments confirmed that secondary lichen metabolites have got many biological properties including antimicrobial, antiviral, antioxidant and cancer-chemopreventive [2,3]. Parietin (1), parietinic acid (2), emodin (3), fallacinal (4), teloschistin (5) and their pro-medicines were isolated by using high-performance liquid chromatography (HPLC) and their structures determined by spectroscopic methods including nuclear magnetic resonance (NMR). Furthermore, the activity assay for the pro medicines and some of its metabolites showed strong antifungal effects. Our results are similar for the data obtained by Manojlović et al. [4]. Compounds 1 – 5 exhibited also medium antibacterial activity. Further, the activity using a battery of 13 luciferase cancer-related reporter gene assays for the pro medicines and some of its metabolites showed that 1 has got a significant cancer-chemopreventive activity. However, only weak activities were observed for 2 and 3. The present study suggests that further investigation of pharmacological properties of the secondary lichen metabolites is warranted to support their use in traditional medicine and to understand their metabolic fate or deposition in human organism.

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Keywords: HPLC, NMR, secondary lichen metabolites, methanol extract.

References:

[1] Molnára K, Farkas E. Current results on biological activities of lichen secondary Metabolites: a review. Z Naturforsch C 2010; 65: 157 – 173

[2] Łaska G, Kiercul S. Pharmacological activity of secondary metabolites isolated from Xanthoparmelia conspersa (Ehrh. ex Ach.) Hale lichen. Planta Med 2014; 80: 835

[3] Łaska G, Kiercul S, Stocki M, Bajguz A, Pasco DS. Cancer-chemopreventive actvity of secondary metabolites isolated from Xanthoparmelia conspersa (Ehrh. ex Ach.) Hale lichen. Planta Med 2015; 81: 59

[4] Manojlović NT, Solujić S, Sukdolak S, Krstić Lj. Isolation and antimicrobial activity of antraquinones from some species of the lichen genus Xanthoria. J Serb Chem Soc 2000; 65: 555 – 560