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J Neurol Surg A Cent Eur Neurosurg 2017; 78(06): 561-565
DOI: 10.1055/s-0036-1593959
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Predicting Tissue Breaking Strengths in the Epileptic Brain with T2 Relaxometry: Application of Pulsed Water Jet Dissection System for Epilepsy Surgery

Yoko Takahashi
1   Department of Neurosurgery, Tohoku University, Sendai, Japan
,
Masaki Iwasaki
1   Department of Neurosurgery, Tohoku University, Sendai, Japan
,
Atsuhiro Nakagawa
1   Department of Neurosurgery, Tohoku University, Sendai, Japan
,
Shiho Sato
2   Department of Diagnostic Radiology Tohoku University, Sendai, Japan
,
Nobukazu Nakasato
3   Department of Epileptology, Tohoku University, Sendai, Japan
,
Teiji Tominaga
1   Department of Neurosurgery, Tohoku University, Sendai, Japan
› Author Affiliations
Further Information

Publication History

02 May 2016

14 September 2016

Publication Date:
30 November 2016 (online)

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Abstract

Background The piezo actuator-driven pulsed water jet (ADPJ) system is a novel surgical instrument that enables dissection of tissue without thermal damage. Using the ADPJ system in epilepsy surgery requires prediction of the tissue breaking strength of the epileptic brain. The aim of this study was to elucidate whether magnetic resonance imaging T2 relaxometry could predict the breaking strength.

Methods A total of 12 patients with drug-resistant temporal lobe epilepsy who received surgical treatment were included in the study. All the patients qualified for surgery after a comprehensive preoperative evaluation for the treatment of epilepsy. T2 relaxation time, breaking strength of the hippocampus, and an anterior temporal lobe specimen obtained from surgery with dissection depth determined by the ADPJ system were examined.

Results Preoperative T2 relaxation times of the anterior temporal lobe and hippocampus showed mild positive correlation with breaking strength (R2 = 0.60). The hippocampus showed higher T2 relaxation time than the temporal lobe. Hippocampal sclerosis seemed to have higher breaking strength than other pathologies, suggesting the correlation depends on the anatomical location and histopathology. The dissection depth of the extirpated lesion was negatively correlated with the breaking strength at input voltages of 10 V (R2 = − 0.34) and 20 V (R2 = − 0.20).

Conclusions T2 relaxometry may be useful to predict tissue breaking strength in the epileptic brain that allows safe application of the ADPJ system in epilepsy surgery.

Keywords

water jet dissection - epilepsy surgery - temporal lobe - T2 relaxometry - breaking strength
 

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