CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2017; 21(02): 122-125
DOI: 10.1055/s-0036-1593728
Original Research
Thieme-Revinter Publicações Ltda Rio de Janeiro, Brazil

Fibrotic Tissue and Middle Turbinate Exhibit Similar Mechanical Properties. Is Fibrosis a Solution in Nasal Polyposis?

Luciano Gregório
1   ENT Research Laboratory, Department of ENT, Universidade Federal de São Paulo, São Paulo, SP, Brazil
,
Rogério Pezato
1   ENT Research Laboratory, Department of ENT, Universidade Federal de São Paulo, São Paulo, SP, Brazil
,
Rafael Souza Felici
1   ENT Research Laboratory, Department of ENT, Universidade Federal de São Paulo, São Paulo, SP, Brazil
,
Eduardo Macoto Kosugi
1   ENT Research Laboratory, Department of ENT, Universidade Federal de São Paulo, São Paulo, SP, Brazil
› Institutsangaben
Weitere Informationen

Publikationsverlauf

26. Juli 2016

06. September 2016

Publikationsdatum:
26. Oktober 2016 (online)

Abstract

Introduction Nasal polyposis (NP) is a chronic inflammatory condition of the upper airway characterized by overgrowth of nasal mucosa. Recent studies have shown a mechanical dysfunction in the nasal polyp tissue.

Objective This study aims to evaluate the mechanical properties of nasal fibrotic tissue.

Method This study was an institutional review board approved translational study in 20 participants (8 patients with NP, 7 patients with nasal synechiae, and 5 subjects without sinus disease (control group). We used Controlled Disc Stimulation equipment to compare the curve Pressure/Volume created during the saline solution infusion.

Results The increase of pressure in response to solution injection was lower in the nasal polyp group when compared with control middle turbinate group and fibrotic group. No significant difference was found in the pressure response during solution injection between fibrotic group and control middle turbinate group.

Inferior turbinate group showed significant difference when compared with control middle turbinate group.

Conclusion The mechanical dysfunction found in the nasal mucosa of patients with NP provides new insight into this condition. These data allow the belief that the fibrosis has a potential role in increasing interstitial hydrostatic pressure and, consequently, mitigating edema formation in NP.

 
  • References

  • 1 Pezato R, de Almeida DC, Bezerra TF. , et al. Immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment. Mediators Inflamm 2014; 2014: 583409
  • 2 Van Bruaene N, Derycke L, Perez-Novo CA. , et al. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol 2009; 124 (02) 253-259 , 259.e1–259.e2
  • 3 Balsalobre L, Pezato R, Perez-Novo C. , et al. Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF-β1 as compared with healthy nasal mucosa. J Otolaryngol Head Neck Surg 2013; 42: 29
  • 4 Lee SH, Park JH, Oh BH. , et al. Analysis of proteoglycan gene messages in human nasal mucosa and nasal polyp using dot blot hybridization. Acta Otolaryngol 2001; 121 (03) 398-402
  • 5 Liu Z, Gao Q, Zhang S, You X, Cui Y. [Expression of tenascin and fibronectin in nasal polyps]. Zhonghua Er Bi Yan Hou Ke Za Zhi 2002; 37 (03) 173-176
  • 6 Pezato R, Voegels RL, Pinto Bezerra TF, Perez-Novo C, Stamm AC, Gregorio LC. Mechanical disfunction in the mucosal oedema formation of patients with nasal polyps. Rhinology 2014; 52 (02) 162-166
  • 7 Fokkens WJ, Lund VJ, Mullol J. , et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012; 50 (01) 1-12
  • 8 Yang YC, Zhang N, Van Crombruggen K, Hu GH, Hong SL, Bachert C. Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling. Allergy 2012; 67 (10) 1193-1202
  • 9 Pezato R, Voegels RL. Why do we not find polyps in the lungs? Bronchial mucosa as a model in the treatment of polyposis. Med Hypotheses 2012; 78 (04) 468-470
  • 10 Pezato R, Voegels RL, Stamm AC, Gregório LC. Why we should avoid using inferior turbinate tissue as control to Nasal Polyposis studies. Acta Otolaryngol 2016; 136 (09) 973-975
  • 11 Berger G, Finkelstein Y, Ophir D, Landsberg R. Old and new aspects of middle turbinate histopathology. Otolaryngol Head Neck Surg 2009; 140 (01) 48-54
  • 12 Wang Y, Lee HP, Gordon BR. Impacts of fluid dynamics simulation in study of nasal airflow physiology and pathophysiology in realistic human three-dimensional nose models. Clin Exp Otorhinolaryngol 2012; 5 (04) 181-187
  • 13 Takeno S, Yoshimura H, Kubota K, Taruya T, Ishino T, Hirakawa K. Comparison of nasal nitric oxide levels between the inferior turbinate surface and the middle meatus in patients with symptomatic allergic rhinitis. Allergol Int 2014; 63 (03) 475-483