CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2017; 06(03): 213-215
DOI: 10.1055/s-0036-1593604
Case Report
Thieme Medical and Scientific Publishers Private Ltd.

Meningioma with Metastatic Malignant Melanoma: An Unusual Coincidence

H. V. Savant
1   Department of Neurosurgery, BYL Nair Hospital and TN Medical College, Mumbai, Maharashtra, India
,
Anand Doshi
1   Department of Neurosurgery, BYL Nair Hospital and TN Medical College, Mumbai, Maharashtra, India
,
Zafar H. Sheikh
1   Department of Neurosurgery, BYL Nair Hospital and TN Medical College, Mumbai, Maharashtra, India
,
Vijay Mahajan
1   Department of Neurosurgery, BYL Nair Hospital and TN Medical College, Mumbai, Maharashtra, India
› Institutsangaben
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Publikationsverlauf

24. Juni 2015

25. Juli 2016

Publikationsdatum:
09. Mai 2017 (online)

Abstract

Simultaneous occurrence of meningioma and brain metastasis as two different histopathologically-proven lesions has been often reported in literature, however, to the best of our knowledge, contiguous occurrence of meningioma and malignant melanoma has not been reported previously in literature. A 50-year-old woman presented with features of raised intracranial pressure and left upper motor neuron signs. Imaging findings were suggestive of right frontoparietal and right parietal extra-axial space occupying extra-axial lesions. Patient underwent right frontotemporoparietal craniotomy with excision of both tumors under general anesthesia. Histopathological analysis was suggestive of transitional meningioma (World Health Organization [WHO] grade I) and malignant melanoma (WHO grade IV). Simultaneous presence of two tumors in the brain might be of the same or different histopathology. In such dual tumors, metastasis cases are varied and one source of it may be melanoma of the skin. Hence, dermatological examination can reveal the primary source of tumor in select cases.

 
  • References

  • 1 Atkins MB, Sosman JA, Agarwala S. , et al. Temozolomide, thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma: a phase II Cytokine Working Group study. Cancer 2008; 113 (08) 2139-2145
  • 2 Schlagenhauff B, Stroebel W, Ellwanger U. , et al. Metastatic melanoma of unknown primary origin shows prognostic similarities to regional metastatic melanoma: recommendations for initial staging examinations. Cancer 1997; 80 (01) 60-65
  • 3 Balch CM, Houghton AN, Sober AJ, Soong SJ, Atkins MB, Thompson JF. Cutaneous Melanoma. 4th ed. St. Louis, MO: Quality Medical Publishing; 2003
  • 4 Raizer JJ, Hwu WJ, Panageas KS. , et al. Brain and leptomeningeal metastases from cutaneous melanoma: survival outcomes based on clinical features. Neuro-oncol 2008; 10 (02) 199-207
  • 5 Maiuri F, Cappabianca P, Iaconetta G, Esposito F, Messina A. Simultaneous presentation of meningiomas with other intracranial tumours. Br J Neurosurg 2005; 19 (04) 368-375
  • 6 Tokunaga T, Shigemori M, Hirohata M, Sugita Y, Miyagi J, Kuramoto S. Multiple primary brain tumors of different histological types—report of two cases. Neurol Med Chir (Tokyo) 1991; 31 (03) 141-145
  • 7 Burger P, Scheihauer BW, Vogel FC. . Intracranial meninges, In: Surgical pathology of nervous system and its coverings. 4th ed. Philadelphia, Churchill Livingston: 49-71 2002
  • 8 Seckin H, Yigitkanli K, Ilhan O, Han U, Bavbek M. Breast carcinoma metastasis and meningioma. A case report. Surg Neurol 2006; 66 (03) 324-327 , discussion 327
  • 9 Darnell RB, Posner JB. Paraneoplastic syndromes affecting the nervous system. Semin Oncol 2006; 33 (03) 270-298
  • 10 Ko JM, Fisher DE. ; KoJM. A new era: melanoma genetics and therapeutics. J Pathol 2011; 223 (02) 241-250
  • 11 Agarwala SS, Kirkwood JM, Gore M. , et al. Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study. J Clin Oncol 2004; 22 (11) 2101-2107
  • 12 Korn EL, Liu PY, Lee SJ. , et al. Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J Clin Oncol 2008; 26 (04) 527-534
  • 13 Schuchter LM, Haluska F, Fraker D, Elenitsas R. Skin: malignant melanoma. In: Abeloff MD. , ed. Clinical Oncology. Philadelphia: Churchill Livingstone; 1326-7 2000
  • 14 Wen PY, Black PM, Loeffler JS. “Metastatic brain cancer,” in Cancer: Principles and Practice of Oncology. In: DeVita VT, Hellman S, Rosenberg SA. , eds., 6th edition. Philadelphia, PA: Lippincott, Williams & Wilkins; 2001: 2655-2670