Synthesis 2018; 50(10): 1958-1964
DOI: 10.1055/s-0036-1591971
short review
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Aryl Trifluoromethyl Ketones

Wei Wu
State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China   Email: [email protected]
,
Zhiqiang Weng*
State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. of China   Email: [email protected]
› Author Affiliations
We acknowledge the financial support from the National Natural Science Foundation of China (21372044 & 21772022) and Fuzhou University (022494).
Further Information

Publication History

Received: 02 March 2018

Accepted after revision: 05 March 2018

Publication Date:
28 March 2018 (online)


Abstract

Trifluoromethyl ketones have recently been attracting considerable attention because they represent powerful synthetic building blocks with potential pharmaceutical applications. This short review provides an overview of recent development in the synthesis of aryl trifluoromethyl ketones with novel reagents.

1 Introduction

2 Various Methods for the Synthesis of Aryl Trifluoromethyl Ketones­

2.1 Oxidation of Trifluoromethyl Alcohols

2.2 Nucleophilic Trifluoromethylation Reactions

2.3 Electrophilic-Type Reactions

2.4 Recently Developed Direct Trifluoroacetylation

3 Conclusions

 
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