Synlett 2017; 28(01): 103-107
DOI: 10.1055/s-0036-1589709
© Georg Thieme Verlag Stuttgart · New York

Mechanism of Building Block Exchange in Stacks of Self-Replicating Macrocycles

Elio Mattia, Asish Pal, Giulia Leonetti, Sijbren Otto*
  • University of Groningen, Centre for Systems Chemistry, Stratingh Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands   Email:
Further Information

Publication History

Received: 30 September 2016

Accepted after revision: 07 November 2016

Publication Date:
23 November 2016 (eFirst)


Self-replicating molecules containing labile reversible covalent bonds are becoming increasingly topical. Yet their robustness to component exchange and the threat of loss of information has received very little attention. We show here that supramolecular interactions can efficiently protect self-replicating molecules from otherwise rapid component exchange.

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