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Synthesis 2018; 50(04): 778-784
DOI: 10.1055/s-0036-1589140
DOI: 10.1055/s-0036-1589140
paper
Palladium-Catalyzed Synthesis of Aryl and Heteroaryl Difluoromethylated Phosphonates
This work was partially supported by INSA Rouen, Rouen University, CNRS, EFRD, Labex SynOrg (ANR-11-LABX-0029), Région Normandie (Crunch Network) and the IUF (Institut Universitaire de France). M.V.I. thanks the MESR for a doctoral fellowship.Further Information
Publication History
Received: 28 September 2017
Accepted after revision: 26 October 2017
Publication Date:
29 November 2017 (online)
Published as part of the Bürgenstock Special Section 2017 Future Stars in Organic Chemistry
Abstract
We report the palladium-catalyzed introduction of the difluoromethylposphonate unit onto aryl and heteroaryl iodides under mild conditions. Using the CuCF2PO(OEt)2 species generated in situ, the method allows the functionalization of various otherwise reluctant substrates. In addition, this reaction permits the formation of CF2PO(OEt)2-containing heterocycles, an important class of compounds. This process broadens the current toolbox of methods available to construct CF2PO(OEt)2-containing molecules.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1589140.
- Supporting Information
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