An efficient and environmentally benign procedure has been developed for the epoxidation
of naphthoquinone derivatives by using tetrabutylammonium iodide as a catalyst and
tert-butyl hydroperoxide as an oxidant in the presence of silicon dioxide. This protocol,
which provides a facile base-free methodology for the synthesis of some new naphthoquinone-based
epoxides, features mild reaction conditions, high yields, remarkably short reaction
time, and broad substrate scope
Key words
naphthoquinone derivates - expoxidation - tetrabutylammonium iodide -
tert-butyl hydroperoxide - silicon dioxide
