Synthesis 2017; 49(14): 3107-3111
DOI: 10.1055/s-0036-1589023
psp
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Resolution of a Chiral Diamine: 2,2′-(Propane-2,2-diyl)dipyrrolidine

Andreas F. Kotthaus, Frederic Ballaschk, Vjoni Stakaj, Fabian Mohr, Stefan F. Kirsch*
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Publication History

Received: 24 March 2017

Accepted after revision: 07 April 2017

Publication Date:
18 May 2017 (eFirst)

Abstract

A short and practical synthesis of a new chiral dipyrrolidine is presented. The three-step route includes a hydrogenation and a resolution with mandelic acid, which easily affords large quantities of the title compound.

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