Synlett 2017; 28(15): 1873-1884
DOI: 10.1055/s-0036-1589008
© Georg Thieme Verlag Stuttgart · New York

Recent Progress in the Cross-Coupling Reaction Using Triorgano­silyl-Type Reagents

Takeshi Komiyamaa, Yasunori Minami*b, Tamejiro Hiyama*b
  • aDepartment of Applied Chemistry, Chuo University, Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan   Email:
  • bResearch and Development Initiative, Chuo University, Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan   Email:
Further Information

Publication History

Received: 25 February 2017

Accepted after revision: 27 March 2017

Publication Date:
04 May 2017 (eFirst)


The silicon-based cross-coupling reaction has attracted much attention over recent decades because there are many advantages in using organosilicon compounds. However, the use of reagents with a triorganosilyl group as a key function remains to be established. This account summarizes our recent progress in cross-coupling chemistry with such silyl reagents.

1 Introduction

2 Preparation of HOMSi Reagents from Aryl Bromides and Disilanes

3 HOMSi Reagents from Heteroaromatics and Hydrosilanes

4 Cross-Coupling Polymerization with HOMSi Reagents

5 Cross-Coupling with Aryl(triethyl)silanes

6 Amination of Aryl Halides with N-TMS-Amines

7 Conclusion and Perspective