Synthesis 2017; 49(18): 4254-4260
DOI: 10.1055/s-0036-1588998
special topic
© Georg Thieme Verlag Stuttgart · New York

Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation–Cyclization of Allylphenols

Ierasia Triandafillidi
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece   Email: ckokotos@chem.uoa.gr
,
Ioanna K. Sideri
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece   Email: ckokotos@chem.uoa.gr
,
Dimitrios Ioannis Tzaras
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece   Email: ckokotos@chem.uoa.gr
,
Nikoleta Spiliopoulou
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece   Email: ckokotos@chem.uoa.gr
,
Christoforos G. Kokotos*
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece   Email: ckokotos@chem.uoa.gr
› Author Affiliations
Further Information

Publication History

Received: 11 March 2017

Accepted after revision: 22 March 2017

Publication Date:
20 April 2017 (online)

Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

Abstract

A green and cheap protocol for the synthesis of dihydrobenzofurans via an organocatalytic oxidation of o-allylphenols is presented. The use of 2,2,2-trifluoroacetophenone and H2O2 as the oxidation system, leads to a highly useful synthetic method, where a variety of substituted o-allylphenols were cyclized in high yields.

Supporting Information

 
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