Synthesis 2017; 49(01): 96-114
DOI: 10.1055/s-0036-1588878
paper
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Lycopalhine A

Yuji Ochi
,
Satoshi Yokoshima*
,
Tohru Fukuyama*
Further Information

Publication History

Received: 26 July 2016

Accepted after revision: 09 August 2016

Publication Date:
14 September 2016 (online)


Dedicated to Professor Dieter Enders on the occasion of his 70th birthday

Abstract

The total synthesis of lycopalhine A featuring the construction of a tricyclic system via cleavage of a cyclopropane ring and an ensuing intramolecular Michael addition, stereoselective introduction of a 2-aminoethyl moiety via a reaction of allyltrimethylsilane with a sulfonyliminium ion, and a stereoselective intramolecular aldol reaction is reported.

Supporting Information

 
  • References

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