Synlett 2017; 28(15): 1897-1900
DOI: 10.1055/s-0036-1588807
© Georg Thieme Verlag Stuttgart · New York

Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems

School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. of China
Hui Zhao
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. of China
Yuan Tian
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 611756, P. R. of China   Email:
Zi-Gang Li*
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. of China
› Author Affiliations
Supported by: National Natural Science Foundation of China (21102007, 21372023)
Supported by: MOST (2015DFA31590)
Supported by: Shenzhen Science and Technology Innovation Committee (SW201110018, SGLH20120928095602764, ZDSY20130331145112855, JSGG20140519105550503)
Supported by: Shenzhen Peacock Program (KQTD201103)
Further Information

Publication History

Received: 18 February 2017

Accepted after revision: 02 April 2017

Publication Date:
20 April 2017 (eFirst)

Published as part of the Cluster Recent Advances in Protein and Peptide Synthesis


A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is simple, efficient, has minimal cellular toxicity, and might be useful in a wide range of biological research.

Supporting Information

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