Synlett 2017; 28(12): 1389-1393
DOI: 10.1055/s-0036-1588762
© Georg Thieme Verlag Stuttgart · New York

Chemical Protein Synthesis through Selenocysteine Chemistry

Reem Mousaa, Post Sai Reddya, b, Norman Metanis*a
  • aInstitute of chemistry, The Hebrew University of Jerusalem, Safra Campus Givat Ram, Jerusalem 91904, Israel   Email:
  • bInstitut Européen de Chimie et Biologie 2, Rue Robert Escarpit 33607 Pessac Cedex, France
Further Information

Publication History

Received: 06 February 2017

Accepted after revision: 28 February 2017

Publication Date:
21 March 2017 (eFirst)


Methods for the preparation of small-to-medium-sized proteins by chemical protein synthesis have matured in recent years and proven valuable for protein science. Thanks to the many recent discoveries and developments in the field, proteins up to 300 amino acids can now be prepared in the lab in a matter of days. This technology gives the scientists the flexibility to substitute any atom in the protein sequence; hence synthesis is not constrained to the 20 canonical amino acids. In this Synpacts article we briefly highlight the recent studies on selenocysteine chemistry in the field of chemical protein synthesis.

1 Introduction

2 Selenocysteine in Nature and in Folding Studies

3 Selenocysteine in Protein Synthesis

4 Selenocysteine in Natural Selenoproteins

5 Outlook