Synthesis 2017; 49(09): 1969-1971
DOI: 10.1055/s-0036-1588710
psp
© Georg Thieme Verlag Stuttgart · New York

A Practical 11B NMR Evaluation of BH3 Titer in Commercial Solutions

Sonia De Angelis
a  Department of Pharmacy – Drug Sciences, University of Bari ‘A. Moro’, Via E. Orabona 4, Bari 70125, Italy   Email: [email protected]   Email: [email protected]
,
Paolo Celestini
b  COSMA S.p.A, Via Colleoni 15/17, Ciserano (BG) 24040, Italy
,
Gabriele Rebuzzini
b  COSMA S.p.A, Via Colleoni 15/17, Ciserano (BG) 24040, Italy
,
Leonardo Degennaro*
a  Department of Pharmacy – Drug Sciences, University of Bari ‘A. Moro’, Via E. Orabona 4, Bari 70125, Italy   Email: le[email protected]   Email: [email protected]
,
Renzo Luisi*
a  Department of Pharmacy – Drug Sciences, University of Bari ‘A. Moro’, Via E. Orabona 4, Bari 70125, Italy   Email: [email protected]   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 20 December 2016

Accepted after revision: 19 January 2017

Publication Date:
10 February 2017 (online)


Abstract

Many reduction reactions require the use of BH3, which is commercially available as complex in many different solvents. The determination of the content of BH3 in such solutions could be an important issue when the stoichiometry of the reaction is concerned. A fast, direct, and reproducible method to establish the content of BH3 in several solutions based on 11B NMR analysis is reported.

Supporting Information

 
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