Chiron Approaches to the Antitumor Natural Product Fuzanin D
Received: 10 August 2016
Accepted after revision: 17 October 2016
18 November 2016 (eFirst)
Fuzanin D, a pyridine-containing natural product, which exhibits cytotoxic activity against DLD-1 cells, is synthesized in a concise manner using l-arabinose or ethyl l-lactate as chiral pool substrates in nine steps (14.4% overall yield) and six steps (30.8% overall yield), respectively. The key steps involve Wittig olefination and olefin cross-metathesis.