Novel One-Pot Cyclization of the Blaise Reaction Intermediate and Arylglyoxals: The Synthesis of Substituted NH-PyrrolesSupported by: We are grateful for financial support from the National Natural Science Foundation of China Grant / Award number ‘21276237’, ‘21676253’
Received: 06 March 2017
Accepted after revision: 12 March 2017
11 April 2017 (eFirst)
A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively to afford a wide variety of substituted NH-pyrroles in good yields.