Synlett 2017; 28(12): 1463-1466
DOI: 10.1055/s-0036-1588168
letter
© Georg Thieme Verlag Stuttgart · New York

Novel One-Pot Cyclization of the Blaise Reaction Intermediate and Arylglyoxals: The Synthesis of Substituted NH-Pyrroles

Zhiwei Chen*a, b, Hao Chena, b, Xiaofeng Yanga, b, Xiangqing Changa, b
  • aNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. of China
  • bKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   Email: chenzhiwei@zjut.edu.cn
Supported by: We are grateful for financial support from the National Natural Science Foundation of China Grant / Award number ‘21276237’, ‘21676253’
Further Information

Publication History

Received: 06 March 2017

Accepted after revision: 12 March 2017

Publication Date:
11 April 2017 (eFirst)

Abstract

A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively to afford a wide variety of substituted NH-pyrroles in good yields.

Supporting Information