Intracranial Cavernomas: An Institutional Review
18 May 2016
20 June 2016
27 August 2016 (eFirst)
Introduction Intracranial cavernomas are rare vascular malformations accounting for 0.4 to 0.8% of all intracranial lesions. They usually present with seizures and neurological deficits following hemorrhagic episode. Surgical excision can provide lifetime cure from these lesions.
Aims and Objectives The aims and objectives of this study were to study the clinicopathological profile and discuss management strategies affecting the outcome of patients with intracranial cavernomas.
Materials and Methods We have studied patients of intracranial cavernomas operated in our department in the past 5 years. Magnetic resonance imaging of the brain was used as diagnostic modality of choice. Patients' clinical status upon admission and accessibility of the lesion were taken into account for surgical planning.
Observation and Results Most of the patients were young. Twenty-two patients had single and 6 patients had multiple lesions. Patients with supratentorial lesions mainly presented with seizures (75%) wherein infratentorial lesions had cranial nerve palsies and long tract signs (25%). Total surgical excision was achieved in all the patients. No significant postoperative complications were encountered. None of the patient showed recurrence during follow-up period.
Conclusion Patients benefit from modern neurosurgical techniques in contrast to conservative approach in this disease of rather prolonged and unpredictable natural course.
- 1 Aiba T, Tanaka R, Koike T, Kameyama S, Takeda N, Komata T. Natural history of intracranial cavernous malformations. J Neurosurg 1995; 83 (1) 56-59
- 2 Del Curling Jr O, Kelly Jr DL, Elster AD, Craven TE. An analysis of the natural history of cavernous angiomas. J Neurosurg 1991; 75 (5) 702-708
- 3 Kondziolka D, Lunsford LD, Kestle JRW. The natural history of cerebral cavernous malformations. J Neurosurg 1995; 83 (5) 820-824
- 4 Rigamonti D, Drayer BP, Johnson PC, Hadley MN, Zabramski J, Spetzler RF. The MRI appearance of cavernous malformations (angiomas). J Neurosurg 1987; 67 (4) 518-524
- 5 Kondziolka D, Lunsford LD, Flickinger JC, Kestle JR. Reduction of hemorrhage risk after stereotactic radiosurgery for cavernous malformations. J Neurosurg 1995; 83 (5) 825-831
- 6 Maraire JN, Awad IA. Intracranial cavernous malformations: lesion behavior and management strategies. Neurosurgery 1995; 37 (4) 591-605
- 7 Barrow DL, Schuette AJ. Cavernous malformations: a paradigm for progress. Clin Neurosurg 2011; 58: 27-41
- 8 Casazza M, Broggi G, Franzini A , et al. Supratentorial cavernous angiomas and epileptic seizures: preoperative course and postoperative outcome. Neurosurgery 1996; 39 (1) 26-32 , discussion 32–34