Download PDF
CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2018; 07(01): 054-057
DOI: 10.1055/s-0036-1585460
Case Report
Thieme Medical and Scientific Publishers Private Ltd.

Giant Malignant Peripheral Nerve Sheath Tumor of Scalp in Non-neurofibromatosis Person: A Rare Case Report

Amit Gupta
1   Department of Neurosurgery, King Georges Medical Collage, Lucknow, Uttar Pradesh, India
,
Rakesh Kumar
1   Department of Neurosurgery, King Georges Medical Collage, Lucknow, Uttar Pradesh, India
,
Bal Krishna Ojha
1   Department of Neurosurgery, King Georges Medical Collage, Lucknow, Uttar Pradesh, India
,
Anil Chandra
1   Department of Neurosurgery, King Georges Medical Collage, Lucknow, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

Received: 13 February 2016

accepted after revision: 11 March 2016

Publication Date:
12 April 2017 (online)

   Permissions and Reprints

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms, usually arising from components of nerve sheath such as perineural fibroblasts or Schwann cells. Primary scalp MPNST is an exceptionally rare entity and only few cases have been reported till date. We encountered an unusual case of giant scalp MPNST in a 70-year-old man without any history suggestive of neurofibromatosis associated with intracranial extension with underlying bone destruction. The tumor was treated with complete surgical excision followed by adjuvant radiotherapy. Histopathological examination showed hyper- and hypocellular areas of spindle cells admixed with myxoid areas and immunohistochemistry revealed positivity to vimentin and S100 on the basis of which the diagnosis of MPNST was made.

Keywords

malignant peripheral nerve sheath tumor - occipital - scalp - S100 - surgical resection - radiotherapy
 

  • References

  • 1 Angelov L, Davis A, O'Sullivan B, Bell R, Guha A. Neurogenic sarcomas: experience at the University of Toronto. Neurosurgery 1998; 43 (01) 56-64 discussion 64–65
    CrossrefPubMedGoogle Scholar
  • 2 Garg A, Gupta V, Gaikwad SB. et al. Scalp malignant peripheral nerve sheath tumor (MPNST) with bony involvement and new bone formation: case report. Clin Neurol Neurosurg 2004; 106 (04) 340-344
    CrossrefPubMedGoogle Scholar
  • 3 Kumar P, Jaiswal S, Agrawal T, Verma A, Datta NR. Malignant peripheral nerve sheath tumor of the occipital region: case report. Neurosurgery 2007; 61 (06) E1334-E1335 discussion E1335
    CrossrefPubMedGoogle Scholar
  • 4 Sangüeza OP, Requena L. Neoplasms with neural differentiation: a review. Part II: malignant neoplasms. Am J Dermatopathol 1998; 20 (01) 89-102
    CrossrefPubMedGoogle Scholar
  • 5 Ferner RE, Gutmann DH. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Cancer Res 2002; 62 (05) 1573-1577
    PubMedGoogle Scholar
  • 6 Evans DG, Baser ME, McGaughran J, Sharif S, Howard E, Moran A. Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 2002; 39 (05) 311-314
    CrossrefPubMedGoogle Scholar
  • 7 Kapadia SB. Tumors of the nervous system. In: Barnes L. ed. Surgical Pathology of the Head and Neck. New York, NY: Marcel Dekker; 2001: 787-888
    Google Scholar
  • 8 Chen L, Mao Y, Chen H, Zhou LF. Diagnosis and management of intracranial malignant peripheral nerve sheath tumors. Neurosurgery 2008; 62 (04) 825-832 discussion 832
    CrossrefPubMedGoogle Scholar
  • 9 Kourea HP, Bilsky MH, Leung DH, Lewis JJ, Woodruff JM. Subdiaphragmatic and intrathoracic paraspinal malignant peripheral nerve sheath tumors: a clinicopathologic study of 25 patients and 26 tumors. Cancer 1998; 82 (11) 2191-2203
    CrossrefPubMedGoogle Scholar