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J Knee Surg 2017; 30(03): 283-288
DOI: 10.1055/s-0036-1584535
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Can Teicoplanin Be an Effective Choice for Antibiotic-Impregnated Cement Spacer in Two-Stage Revision Total Knee Arthroplasty?

Abdul Fettah Buyuk
1   Department of Orthopaedics and Traumatology, Dogubeyazit State Hospital, Agri, Turkey
,
Hakan Sofu
2   Department of Orthopaedics and Traumatology, Erzincan University Faculty of Medicine, Erzincan, Turkey
,
Ismet Yalkin Camurcu
3   Department of Orthopaedics and Traumatology, Devrek State Hospital, Zonguldak, Turkey
,
Hanifi Ucpunar
4   Department of Orthopaedics and Traumatology, Baltalimani Bone and Joint Diseases Hospital, Istanbul, Turkey
,
Mehmet Akif Kaygusuz
4   Department of Orthopaedics and Traumatology, Baltalimani Bone and Joint Diseases Hospital, Istanbul, Turkey
,
Vedat Sahin
2   Department of Orthopaedics and Traumatology, Erzincan University Faculty of Medicine, Erzincan, Turkey
› Author Affiliations
Further Information

Publication History

21 January 2016

09 May 2016

Publication Date:
30 June 2016 (online)

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Abstract

The main purpose of this study was to evaluate the clinical results of two-stage revision total knee arthroplasty using a teicoplanin-impregnated cement spacer for infected primary total knee replacements. Twenty-five patients operated between 2005 and 2012 were included in this study. At the clinical status analysis, rate of infection eradication was assessed, physical examination was performed, Knee Society Score (KSS) was noted, isolated microorganisms were recorded, and the radiographic evaluation was performed. The mean KSS improved from 40 (range, 25–69) preoperatively to 77 (range, 32–96) at the latest follow-up (p < 0.05). Methicillin-resistant Staphylococcus epidermidis was isolated in 9 of 25 patients as the most frequently isolated pathogen, and the other isolated pathogens were methicillin-susceptible S. epidermidis, methicillin-resistant Staphylococcus aureus, and methicillin-susceptible S. aureus. Infection was successfully eradicated in 24 of 25 patients. Two-stage revision of the infected primary knee replacement is a time-consuming but a reliable procedure with high rates of success. Teicoplanin was found to be an effective choice for antibiotic-impregnated cement spacer applied for the eradication of the infection.

Keywords

Knee arthroplasty - infection - two-stage revision - teicoplanin
 

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