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Rev Bras Ginecol Obstet 2016; 38(04): 177-182
DOI: 10.1055/s-0036-1583172
Original Article
Thieme Publicações Ltda Rio de Janeiro, Brazil

The Association between N-terminal Pro-Brain Natriuretic Peptide Levels in the Umbilical Vein and Amniotic Fluid Volume Abnormalities

Associação entre níveis de peptídeo natriurético pró-cerebral N-terminal na veia umbilical e as anormalidades do volume de líquido amniótico
Ali Ozgur Ersoy
1   Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey
,
Sibel Ozler
1   Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey
,
Efser Oztas
1   Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey
,
Ebru Ersoy
1   Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey
,
Merve Ergin
2   Department of Biochemistry, Ataturk Education and Research Hospital, Ankara, Turkey
,
Salim Erkaya
1   Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey
,
Dilek Uygur
1   Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

11 November 2015

07 January 2016

Publication Date:
20 April 2016 (online)

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Abstract

Purpose The amniotic fluid volume (AFV) is known as a predictor for the wellness of a fetus. We aimed to investigate whether N-terminal pro-brain natriuretic peptide (NTproBNP) levels reflect AFV abnormalities in otherwise normal fetuses.

Methods We recruited 24 women with isolated oligohydramnios, 23 women with isolated polyhydramnios, and 36 women with normal AFV at a tertiary referral center. NT-proBNP levels in umbilical venous samples and the individual characteristics of the three groups were compared. One-way ANOVA and Kruskal–Wallis analysis of variance were used for multi-group comparisons of continuous variables. When a significant difference was detected, the Scheffe test was performed as a post-hoc analysis. Proportions were compared using the Chi-square (χ2) test.

Results Maternal age, body mass indices, weight gained in pregnancy and NT-proBNP levels were similar among the three groups. Apgar scores at 1 and 5 minutes significantly correlated with NT-proBNP levels in all newborns (Spearman's r = 0.23; p = 0.03 and Spearman's r = 0.24; p = 0.02, respectively). The umbilical venous NT-proBNP levels did not differ between newborns who needed mechanical ventilation and those who didn't (p = 0.595).

Conclusions NT-proBNP is a biomolecule that may provide insights into the pathogenesis of fetal circulatory problems and subsequent renal failure. Further investigations are warranted.

Resumo

Objetivo Investigar se os níveis de peptídeo natriurético pró-cerebral N-terminal (NT-proBNP) refletem anormalidades no volume de líquido amniótico (VLA) em fetos normais.

Métodos Reunimos 24 mulheres com oligoidrâmnios isolados, 23 com poli-hidrâmnios isolados, e 36 com VLA normal em um centro de referência. Comparamos os níveis de NT-proBNP em amostras venosas umbilicais e características individuais em três grupos. Usamos análise de variância simples (One-way ANOVA) e a análise de variação Kruskal–Wallis para comparação de variáveis contínuas em múltiplos grupos. Quando identificada uma diferença significativa, o teste de Scheffe foi aplicado como uma análise post-hoc. Comparamos proporções usando o teste Qui-quadrado (χ2).

Resultados Idade fértil, índice de massa corporal, ganho de peso na gestação e níveis de NT-proBNP foram similares nos três grupos. Apgar em 1 e 5 minutos correlacionaram significativamente com os níveis de NT-proBNP em todos os recém-nascidos (Spearman's r = 0,23; p = 0,03 e Spearman's r = 0,24; p = 0,02, respectivamente). Os níves de NT-proBNP venoso umbilical não se distinguiram entre os recém-nascidos que precisaram de ventilação mecânica e aqueles que não precisaram (p = 0,595).

Conclusões NT-proBNP é um candidato biomolecular que pode contribuir na patogênese de problemas circulatórios fetais e subsequente insuficiência renal. São necessárias futuras investigações.

Keywords

amniotic fluid volume - oligohydramnios - polyhydramnios - pregnancy - renal function

Palavras-chave

volume do líquido amniótico - oligoidrâmnios - poli-hidrâmnios - gravidez - função renal
 

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