Cranial Maxillofac Trauma Reconstruction 2017; 10(01): 56-59
DOI: 10.1055/s-0036-1582459
Case Report
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Primary Leiomyosarcoma of the Mandibular Alveolar Mucosa of a 12-Year-Old Child from Ethiopia: A Case Report

Tewodros Tefera Kenea1, Betel Abebe Kebede2, Fekadu Mesele Gozjuze3, Hagos Kiros4, Frank Wilde5
  • 1Department of Cranio-Maxillofacial and Oral Surgery, Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia
  • 2Department of Pediatrics and Child Health, Addis Ababa University, Addis Ababa, Ethiopia
  • 3Dental and Stomatology, Haramaya University, Harar, Ethiopia
  • 4Department of Pathology, Addis Ababa University, Addis Ababa, Ethiopia
  • 5Department of Oral and Maxillofacial Surgery, Military Hospital Ulm, Academic Hospital Ulm University, Ulm, Germany
Further Information

Publication History

09 August 2015

06 December 2015

Publication Date:
27 April 2016 (eFirst)


Leiomyosarcomas (LMSs) are rare malignant mesenchymal tumors which show smooth-muscle differentiation. Most LMSs involving the oral tissues primarily affect the maxillary sinus, the maxillary or mandibular bone. We present a case of LMS of the mandibular alveolar mucosa, arising in a 12-year-old male child from Ethiopia. A malignant spindle cell-like neoplasm was diagnosed on clinical and radiographic findings as well as on incisional biopsy. The tumor was resected with wide margins. The following histopathologic examination with additional immunohistochemical studies secured the diagnosis LMS. Microscopically, the spindle-shaped tumor cells were arranged in an interlacing fascicular pattern and contained oval to elongated, blunt-ended (cigar-shaped) nuclei. The immunohistochemical examination showed immunoreactive tumor cells for vimentin, actin, desmin, and H-caldesmon, which is pathognomonic for LMS. Immunohistochemical studies are mandatory to differentiate the LMS from other similar spindle cell neoplastic lesions. Radical resection with safety margins and a lifelong periodic follow-up has to be recommended.