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Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2016; 35(02): 169-173
DOI: 10.1055/s-0036-1581083
Case Report | Relato de Caso
Thieme Publicações Ltda Rio de Janeiro, Brazil

Successful Propranolol Treatment of Multiple Infantile Hemangiomas with Predominant Neuroaxial Involvement: a Case Report

Hemangioma múltiplo da infância com envolvimento predominantemente neuroaxial tratado com propranolol: relato de caso
Angela F. de A. Bocchese
1   School of Medicine, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brazil
,
Gregori Manfroi
1   School of Medicine, Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brazil
2   Liga Acadêmica do Serviço de Neurologia e Neurocirurgia, Hospital da Cidade de Passo Fundo, Passo Fundo, RS, Brazil
,
Paulo M. Mesquita Filho
2   Liga Acadêmica do Serviço de Neurologia e Neurocirurgia, Hospital da Cidade de Passo Fundo, Passo Fundo, RS, Brazil
3   Department of Neurosurgery, Hospital da Cidade de Passo Fundo, Passo Fundo, RS, Brazil
4   School of Medicine, Instituto Meridional (IMED), Passo Fundo, RS, Brazil
,
Pablo Santiago
5   Pediatric Oncologist, Associate Professor at the UPF, Passo Fundo, RS, Brazil
,
Fábio P. Santos
6   Otolaryngologist, Associate Professor at the UPF, Passo Fundo, RS, Brazil
› Author Affiliations
Further Information

Publication History

09 November 2015

19 January 2016

Publication Date:
14 April 2016 (online)

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Abstract

Infantile hemangiomas (IH) are the most common vascular tumor of infancy. Occurrences during the neonatal period are divided in multiple congenital, limited to skin involvement, or diffuse neonatal hemangiomatosis (DNH). DNH is considered to be a benign and rare disease, determined by the presence of multiple cutaneous and extracutaneous hemangiomas. The encephalic and medullary involvement of IHs is unusual and rarely reported. The authors report a case of infantile hemangioma (IH) as diffuse neonatal hemangiomatosis with predominant central nervous system involvement on a neonate, treated with propranolol. We discuss the use propranolol as main therapy and review the available data regarding IHs with neuroaxial involvement and its treatment.

Resumo

Hemangiomas da infância (HI) são o tipo mais comum de tumores vasculares nessa faixa etária, e, quando no período neonatal, podem ser divididos em múltiplos congênitos, limitados ao envolvimento cutâneo, ou hemangiomatose neonatal difusa (HND). A HND é considerada uma doença rara e benigna, determinada pela presença de múltiplos hemangiomas cutâneos e extracutâneos. O envolvimento encefálico e medular nos HI é incomum e raramente reportado. Relatamos um caso de hemangioma da infância na forma de hemangiomatose neonatal difusa com acometimento predominante do sistema nervoso central tratado com propranolol em neonato. São discutidos o uso de propranolol como terapia de escolha e a revisão de literatura sobre HI com envolvimento neuroaxial e sua terapêutica.

Keywords

hemangioma - infantile - vascular neoplasm - neonate - central nervous system - propranolol

Palavras-chave

hemangioma - infância - tumor vascular - neonato - sistema nervoso central - propranolol
 

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