J Neurol Surg B Skull Base 2016; 77(02): 081-085
DOI: 10.1055/s-0036-1579778
Review Article
Georg Thieme Verlag KG Stuttgart · New York

An Overview of Head and Neck Malignancy with Perineural Spread

Benedict J. Panizza
1   Queensland Skull Base Unit and Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia
2   School of Medicine, University of Queensland, Brisbane, Australia
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2016 (online)

Abstract

This article provides an overview of perineural spread of head and neck malignancy. It defines the problem and explores some of the unique features, which occur with this pathology. The expectation is for a better understanding of this extraordinary disease, hopefully leading to earlier diagnosis and for a more consistent reporting of results. It summarizes the topics to be covered in this special edition, which should leave the reader with a fairly complete understanding of the contemporary issues of perineural spread.

 
  • References

  • 1 Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007; 117 (5) 1137-1146
  • 2 Cernea CR, Ferraz AR, de Castro IV , et al. Perineural invasion in aggressive skin carcinomas of the head and neck. Potentially dangerous but frequently overlooked. ORL J Otorhinolaryngol Relat Spec 2009; 71 (1) 21-26
  • 3 Scanlon CS, Banerjee R, Inglehart RC , et al. Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Nat Commun 2015; 6: 6885
  • 4 Ross AS, Whalen FM, Elenitsas R, Xu X, Troxel AB, Schmults CD. Diameter of involved nerves predicts outcomes in cutaneous squamous cell carcinoma with perineural invasion: an investigator-blinded retrospective cohort study. Dermatol Surg 2009; 35 (12) 1859-1866
  • 5 Warren TA, Whiteman DC, Porceddu SV, Panizza BJ. Insight into the epidemiology of cutaneous squamous cell carcinoma with perineural spread. Head Neck 2016; (e-pub ahead of print). doi: 10.1002/hed.24453
  • 6 Warren TA, Panizza B, Porceddu SV , et al. Outcomes after surgery and postoperative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma. Head Neck 2014; (e-pub ahead of print). doi:10.1002/hed.23982
  • 7 Baulch J, Gandhi M, Sommerville J, Panizza B. 3T MRI evaluation of large nerve perineural spread of head and neck cancers. J Med Imaging Radiat Oncol 2015; 59 (5) 578-585
  • 8 AJCC. Cutaneous squamous cell carcinoma and other cutaneous carcinomas. In: Edge SB, Byrd DR, Compton CC, et al., eds. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer; 2010: 301-314
  • 9 Chawla S, Warren TA, Wockner LF , et al. Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunol Immunother 2016; 65 (2) 213-222
  • 10 Ballantyne AJ, McCarten AB, Ibanez ML. The extension of cancer of the head and neck through peripheral nerves. Am J Surg 1963; 106: 651-667