J Neurol Surg Rep 2016; 77(02): e77-e82
DOI: 10.1055/s-0036-1579629
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Sunitinib as Neoadjuvant Chemotherapy in the Management of Metastatic Renal Cell Carcinoma Mimicking a Glomus Vagale Tumor in the Head and Neck: A Case Report and Review of Literature

Serkan Erkan
1  Department of Otolaryngology, Head and Neck Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
,
Jessica Somner
2  Department of Otolaryngology, Head and Neck Surgery, University of Western Australia, Nedlands, Western Australia, Australia
,
Gunesh P. Rajan
1  Department of Otolaryngology, Head and Neck Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
3  Department of Otolaryngology, Head and Neck Surgery, School of Surgery, University of Western Australia, Murdoch, Western Australia, Australia
› Author Affiliations
Further Information

Publication History

08 August 2015

03 January 2016

Publication Date:
26 May 2016 (online)

Abstract

Background Metastatic renal cell carcinoma (RCC) of the head and neck with intracranial extension is rare and may pose difficulties to the diagnosis and management.

Method We describe a unique case of a 76-year-old man with a metastatic RCC to the neck and lateral skull base with intracranial extension presenting with Collet-Sicard syndrome 8 years after initial diagnosis. The radiologic features were consistent with the diagnosis of a glomus vagale tumor on the basis of clinical and radiologic features.

Results Despite radiotherapy, the intracranial extension progressed in size, resulting in early hydrocephalus. Sunitinib, a novel tyrosine kinase inhibitor, was instituted to treat the glomus vagale tumor with a marked reduction in tumor volume and resolution of the early hydrocephalus. The surgical resection of the tumor with its intracranial extension was achieved without additional postoperative morbidity. The histopathologic diagnosis surprisingly demonstrated metastatic RCC.

Conclusion We present a case of metastatic RCC to the head and neck region mimicking a glomus vagale tumor and describe the first use of sunitinib as a neoadjuvant chemotherapy to achieve a single-stage radical en bloc resection of the tumor mass.

Note

Below manuscript has not been previously published in whole or in part or submitted elsewhere for review.