Planta Med 2016; 82 - PC83
DOI: 10.1055/s-0036-1578785

Phytochemical And Biological Evaluation Of Alcea Rosea L., Growing In Egypt

NM Abd El-Salam 1, MM Radwan 1, 2, AS Wanas 2, 3, ML Shenouda 1, SM Sallam 1, S Piacente 4, MA ElSohly 2, 5, NA Ghazy 1
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21215, Egypt
  • 2National Center for Natural Products Research
  • 3Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
  • 4Salerno University, Department of Pharmacia, 84084 Fisciano (Salerno), Italy
  • 5Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University MS 38677, USA

Alcoholic extract of Alcea rosea flowers and roots exhibited significant immunostimulant and anticancer activities [1]. Bioactivity-guided fractionation of flowers of A. rosea led to the isolation of six compounds (1 – 6). Their structure elucidation was achieved using spectroscopic techniques, including 1D and 2D NMR. Their chemical structures were identified as dihydrokaempferol-4'-O-β-D-glucopyranoside (1), dihydrokaempferol (2), apigenin (3), kaempferol-3-O-α-L-rhamnopyranosyl-(1'''→6'')-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), and kaempferol-3-O-[6''-(E-coumaroyl)]-β-D-glucopyranoside (6). Compounds 1 and 3 showed strong antioxidant and anticancer activities.

Fig. 1

Refrences: [1] Matsuda, Hisashi, et al. "Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action." Bioorganic & medicinal chemistry 10.3 (2002): 707 – 712.