Planta Med 2016; 82 - PC82
DOI: 10.1055/s-0036-1578784

Phytochemical Investigation Of Senecio Vulgaris L.

HM Hammoda 1, FF Kassem 1, MM Radwan 1, 2, AS Wanas 1, 3, RS Darwish 1, MA ElSohly 1, 4, AAM Habib 1
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21215, Egypt
  • 2National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA
  • 3Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt
  • 4Deprtment of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, MS 38677, USA

Senecio vulgaris L. is a well-known toxic plant. Phytochemical investigation of the whole plant afforded the isolation of a new coumarin; 3-hydroxy-5, 6-dimethoxycoumarin-7-O-β-D-glucoside (1), in addition to isorhamnetin-3-O-β-D-glucoside (2) and two known alkaloids of common occurrence in genus Senecio; seneciphylline (3) and senecionine (4) [1 – 2]. The isolated compounds were identified by physical and chemical analyses as well as intensive spectroscopic investigation (1D, 2D NMR and UV). The ethanol extract, petroleum ether and chloroform fractions of S. vulgaris were found to have cytotoxic activity on colorectal HCT-16 cell line, with IC50 values of 19.9, 27.3 and 17.8 µg mL-1, respectively. That indicates the most active cytotoxic fraction is the alkaloid-bearing chloroform fraction. These findings promote the future perspective of S. vulgaris as anticancer agent.

Fig. 1

References: [1] Mansour, R.M.A. and Saleis, N.A.M., "Flavonoids of Three Local Senecio Species", Phytochemistry, 20, 1180 – 1 (1981(. [2] Segall, H.J. and Dallas, J.L., "1H NMR Spectroscopy of pyrrolizidine alkaloids", Phytochemistry, 22, 1271 – 3 (1983).