Planta Med 2016; 82 - PB28
DOI: 10.1055/s-0036-1578676

Mendelian Population Can Let Extraction Rate Of Medical Herb Be Stable

WL Liu 1, 2, XL Zhang 1, W Ouyang 1, HY Huang 1, XQ Xiao 1, PA Liu 1, FY He 1
  • 1School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China
  • 2Department of Biomolecular Sciences and Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Ms 38677, USA

Over the past 20 years, the quality instability of medicinal herbs (QIMH) has stimulated research in the world, revealing that the crucial factors are Good Agriculture Practice and Good Manufacturing Practice. A classical view argues that QIMH controlled by these laws should have a good identical quality and the same extraction rate [1]. However, it is now clear that the considerable variation of the extraction rate among the batches caused different qualities and unstable clinical effects of the herbal extraction [2]. In this research Mendelian population firstly went forward into pharmaceutics field to steady the extraction rate of medical herbs under the controlled conditions. Based on the inter simple sequence repeat (ISSR) markers results that indicated the individual plant had genetic diversity, a Mendelian population of houttuynia cordata thunb (n) was examined through entropy of information (H). The experiments presented the results that H value ranged from 0.3656 to 0.9786, and n was 863 individual houttuynia plants, whose weight (w) was 11.22 kg if calculated as 13.0 g per individual plant. After verification tests, the several-fold n of houttuynia cordata thunb can let its extraction rate be stable. This is a novel view to stabilize the herbal extraction rate, which will contribute to a vital improvement of the classical theory.

Acknowledgements: This research was supported by NSFC (30901971, 81270055), HNNSF (14JJ2110) and by CSC (201408430197).

References: [1] HeTian-tian. et al. (2015) European Journal of Integrative Medicine, 7:55 – 66. [2] Li Changtian et al. (2014) In Journal of Ginseng Research, 38:227 – 232.